ECG markers associated with ischemic stroke at young age - a case-control study
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Pirinen , J , Eranti , A , Knekt , P , Lehto , M , Martinez-Majander , N , Aro , A L , Rissanen , H , Heliövaara , M , Kaste , M , Tatlisumak , T , Huikuri , H & Putaala , J 2017 , ' ECG markers associated with ischemic stroke at young age - a case-control study ' , Annals of Medicine , vol. 49 , no. 7 , pp. 562-568 . https://doi.org/10.1080/07853890.2017.1348620
| Title: | ECG markers associated with ischemic stroke at young age - a case-control study |
| Author: | Pirinen, Jani; Eranti, Antti; Knekt, Paul; Lehto, Mika; Martinez-Majander, Nicolas; Aro, Aapo L.; Rissanen, Harri; Heliövaara, Markku; Kaste, Markku; Tatlisumak, Turgut; Huikuri, Heikki; Putaala, Jukka |
| Contributor organization: | Clinicum Department of Diagnostics and Therapeutics University of Helsinki Department of Neurosciences Neurologian yksikkö Kardiologian yksikkö Department of Medicine HUS Neurocenter HUS Heart and Lung Center HUS Medical Imaging Center HYKS erva Päijät-Häme Welfare Consortium |
| Date: | 2017 |
| Language: | eng |
| Number of pages: | 7 |
| Belongs to series: | Annals of Medicine |
| ISSN: | 0785-3890 |
| DOI: | https://doi.org/10.1080/07853890.2017.1348620 |
| URI: | http://hdl.handle.net/10138/311432 |
| Abstract: | Introduction: Certain electrocardiographic (ECG) abnormalities are associated with ischemic stroke (IS), especially cardioembolic subtype. Besides atrial fibrillation, markers of left ventricular hypertrophy (LVH) or atrial pathology also reflect elevated risk. We studied the association of ECG markers with IS in young adults. Methods: We performed a case-control study including 567 consecutive IS patients aged 15-49 years (inclusion period: 1994-2007) and one or two age-and sex-matched control subjects enrolled during 1978-1980 (n = 1033), and investigated also the stroke aetiologic subgroups. We studied ECGs of all participants for markers of atrial abnormality, i.e. P-terminal force (PTF) on lead V1, interatrial blocks (IAB; P-wave duration >= 110ms), and LVH. Conditional logistic regression analyses were used. Results: IAB (hazard ratio [HR]: 1.57, 95% confidence interval [CI]: 1.16-2.13) and PTF combined with LVH (HR: 6.83, 95% CI: 1.65-28.31), were independently associated with IS. LVH, abnormal P-wave (HR: 6.87, 95% CI: 1.97-135.29), PTF, IAB, and combinations of these P-wave abnormalities with LVH - were associated with cardioembolic subtype. Abnormal P-wave and IAB were associated with cryptogenic stroke subtype. In unadjusted analysis, LVH was associated with small-vessel disease subtype. Conclusion: P-wave abnormalities on ECG were associated with cardioembolic but also with a cryptogenic subtype of IS. |
| Subject: |
Cardioembolism
case-control study cryptogenic stroke electrocardiographic embolic strokes of undetermined source left ventricular hypertrophy P-wave stroke stroke in the young LEFT-VENTRICULAR HYPERTROPHY LEFT ATRIAL ABNORMALITIES P-WAVE MORPHOLOGY INTERATRIAL BLOCK TERMINAL FORCE HYPERTENSIVE PATIENTS ATHEROSCLEROSIS RISK GENERAL-POPULATION PREDICTING STROKE EMBOLIC STROKE 3121 General medicine, internal medicine and other clinical medicine 3112 Neurosciences 3124 Neurology and psychiatry |
| Peer reviewed: | Yes |
| Usage restriction: | openAccess |
| Self-archived version: | acceptedVersion |
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