ECG markers associated with ischemic stroke at young age - a case-control study

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Pirinen , J , Eranti , A , Knekt , P , Lehto , M , Martinez-Majander , N , Aro , A L , Rissanen , H , Heliövaara , M , Kaste , M , Tatlisumak , T , Huikuri , H & Putaala , J 2017 , ' ECG markers associated with ischemic stroke at young age - a case-control study ' , Annals of Medicine , vol. 49 , no. 7 , pp. 562-568 . https://doi.org/10.1080/07853890.2017.1348620

Title: ECG markers associated with ischemic stroke at young age - a case-control study
Author: Pirinen, Jani; Eranti, Antti; Knekt, Paul; Lehto, Mika; Martinez-Majander, Nicolas; Aro, Aapo L.; Rissanen, Harri; Heliövaara, Markku; Kaste, Markku; Tatlisumak, Turgut; Huikuri, Heikki; Putaala, Jukka
Contributor organization: Clinicum
Department of Diagnostics and Therapeutics
University of Helsinki
Department of Neurosciences
Neurologian yksikkö
Kardiologian yksikkö
Department of Medicine
HUS Neurocenter
HUS Heart and Lung Center
HUS Medical Imaging Center
HYKS erva
Päijät-Häme Welfare Consortium
Date: 2017
Language: eng
Number of pages: 7
Belongs to series: Annals of Medicine
ISSN: 0785-3890
DOI: https://doi.org/10.1080/07853890.2017.1348620
URI: http://hdl.handle.net/10138/311432
Abstract: Introduction: Certain electrocardiographic (ECG) abnormalities are associated with ischemic stroke (IS), especially cardioembolic subtype. Besides atrial fibrillation, markers of left ventricular hypertrophy (LVH) or atrial pathology also reflect elevated risk. We studied the association of ECG markers with IS in young adults. Methods: We performed a case-control study including 567 consecutive IS patients aged 15-49 years (inclusion period: 1994-2007) and one or two age-and sex-matched control subjects enrolled during 1978-1980 (n = 1033), and investigated also the stroke aetiologic subgroups. We studied ECGs of all participants for markers of atrial abnormality, i.e. P-terminal force (PTF) on lead V1, interatrial blocks (IAB; P-wave duration >= 110ms), and LVH. Conditional logistic regression analyses were used. Results: IAB (hazard ratio [HR]: 1.57, 95% confidence interval [CI]: 1.16-2.13) and PTF combined with LVH (HR: 6.83, 95% CI: 1.65-28.31), were independently associated with IS. LVH, abnormal P-wave (HR: 6.87, 95% CI: 1.97-135.29), PTF, IAB, and combinations of these P-wave abnormalities with LVH - were associated with cardioembolic subtype. Abnormal P-wave and IAB were associated with cryptogenic stroke subtype. In unadjusted analysis, LVH was associated with small-vessel disease subtype. Conclusion: P-wave abnormalities on ECG were associated with cardioembolic but also with a cryptogenic subtype of IS.
Subject: Cardioembolism
case-control study
cryptogenic stroke
electrocardiographic
embolic strokes of undetermined source
left ventricular hypertrophy
P-wave
stroke
stroke in the young
LEFT-VENTRICULAR HYPERTROPHY
LEFT ATRIAL ABNORMALITIES
P-WAVE MORPHOLOGY
INTERATRIAL BLOCK
TERMINAL FORCE
HYPERTENSIVE PATIENTS
ATHEROSCLEROSIS RISK
GENERAL-POPULATION
PREDICTING STROKE
EMBOLIC STROKE
3121 General medicine, internal medicine and other clinical medicine
3112 Neurosciences
3124 Neurology and psychiatry
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: acceptedVersion


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