Brain-derived neurotrophic factor in mood disorders and antidepressant treatments

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http://hdl.handle.net/10138/311483

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Castrén , E & Kojima , M 2017 , ' Brain-derived neurotrophic factor in mood disorders and antidepressant treatments ' , Neurobiology of Disease , vol. 97 , pp. 119-126 . https://doi.org/10.1016/j.nbd.2016.07.010

Title: Brain-derived neurotrophic factor in mood disorders and antidepressant treatments
Author: Castrén, Eero; Kojima, Masami
Other contributor: University of Helsinki, Neuroscience Center

Date: 2017-01
Language: eng
Number of pages: 8
Belongs to series: Neurobiology of Disease
ISSN: 0969-9961
DOI: https://doi.org/10.1016/j.nbd.2016.07.010
URI: http://hdl.handle.net/10138/311483
Abstract: Levels of brain-derived neurotrophic factor (BDNF) are reduced in the brain and serum of depressed patients and at least the reduction in serum levels is reversible upon successful treatment. These data, together with a wealth of reports using different animal models with depression-like behavior or manipulation of expression of BDNF or its receptor TrkB have implicated BDNF in the pathophysiology of depression as well as in the mechanism of action of antidepressant treatments. Recent findings have shown that posttranslational processing of BDNF gene product can yield different molecular entities that differently influence signaling through BNDF receptor TrkB and the pan-neurotrophin receptor p75(NTR). We will here review these data and discuss new insights into the possible pathophysiological roles of those new BDNF subtypes as well as recent findings on the role of BDNF mediated neuronal plasticity in mood disorders and their treatments. (C) 2016 Elsevier Inc All rights reserved.
Subject: Neurotrophic factors
Neurotrophins
Depression
Anxiety
BDNF
BDNF VAL66MET POLYMORPHISM
TREATMENT-RESISTANT DEPRESSION
RANDOMIZED CONTROLLED-TRIAL
GROWTH CONE RETRACTION
ANXIETY-LIKE BEHAVIOR
LONG-TERM DEPRESSION
RAT-BRAIN
ELECTROCONVULSIVE SEIZURES
HIPPOCAMPAL NEUROGENESIS
SYNAPTIC PLASTICITY
3112 Neurosciences
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