Chronic fluoxetine administration enhances synaptic plasticity and increases functional dynamics in hippocampal CA3-CA1 synapses

Show full item record



Permalink

http://hdl.handle.net/10138/311484

Citation

Popova , D , Castren , E & Taira , T 2017 , ' Chronic fluoxetine administration enhances synaptic plasticity and increases functional dynamics in hippocampal CA3-CA1 synapses ' , Neuropharmacology , vol. 126 , pp. 250-256 . https://doi.org/10.1016/j.neuropharm.2017.09.003

Title: Chronic fluoxetine administration enhances synaptic plasticity and increases functional dynamics in hippocampal CA3-CA1 synapses
Author: Popova, Dina; Castren, Eero; Taira, Tomi
Contributor: University of Helsinki, Neuroscience Center
University of Helsinki, Neuroscience Center
University of Helsinki, Departments of Faculty of Veterinary Medicine
Date: 2017-11
Language: eng
Number of pages: 7
Belongs to series: Neuropharmacology
ISSN: 0028-3908
URI: http://hdl.handle.net/10138/311484
Abstract: Recent studies demonstrate that chronic administration of the widely used antidepressant fluoxetine (FLX) promotes neurogenesis, synaptogenesis and synaptic plasticity in the adult hippocampus, cortex and amygdala. However, the mechanisms underlying these effects and how are they related to the clinical antidepressant efficacy are still poorly understood. We show here that chronic FLX administration decreases hippocampus-associated neophobia in naive mice. In parallel, electrophysiological recordings in hippocampal CA3-CA1 circuitry revealed that the FLX treatment resulted in increased short and long-term plasticity likely attributed to changes in presynaptic function. These changes were accompanied by enhancement in the expression of proteins related to vesicular trafficking and release, namely synaptophysin, synaptotagmin 1, MUNC 18 and syntaxin 1. Thus, chronic FLX administration is associated with enhanced synaptic dynamics atypical of mature CA1 synapses, elevated hippocampal plasticity, improved hippocampus-dependent behavior as well as altered expression of synaptic proteins regulating neurotransmitter trafficking and release. The results support the idea that antidepressants can promote neuronal plasticity and show that they can increase the functional dynamic range and information processing in synaptic circuitries. (C) 2017 Elsevier Ltd. All rights reserved.
Subject: Synaptic plasticity
Fluoxetine
LONG-TERM POTENTIATION
CRITICAL PERIOD
AMPA RECEPTORS
CA1 SYNAPSES
MATURATION
LTP
TRANSMISSION
EXPRESSION
RELEASE
ANTIDEPRESSANTS
3112 Neurosciences
317 Pharmacy
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
Poopova_et_al_resub_010717.pdf 445.2Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record