Immediate verbal recall and familial dementia risk: population-based study of over 4000 twins

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http://hdl.handle.net/10138/311502

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Lindgren , N , Kaprio , J , Rinne , J & Vuoksimaa , E 2019 , ' Immediate verbal recall and familial dementia risk: population-based study of over 4000 twins ' , Journal of Neurology, Neurosurgery and Psychiatry , vol. 90 , no. 1 , pp. 90-97 . https://doi.org/10.1136/jnnp-2018-319122

Title: Immediate verbal recall and familial dementia risk: population-based study of over 4000 twins
Author: Lindgren, Noora; Kaprio, Jaakko; Rinne, Juha; Vuoksimaa, Eero
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
Date: 2019-01
Language: eng
Number of pages: 8
Belongs to series: Journal of Neurology, Neurosurgery and Psychiatry
ISSN: 0022-3050
URI: http://hdl.handle.net/10138/311502
Abstract: Objective To investigate the effect of familial risk for dementia on verbal learning by comparing cognitively healthy twins who had demented co-twins with cognitively healthy twins who had cognitively healthy co-twins. Methods 4367 twins aged >= 65 years including 1375 twin pairs (533 monozygotic (MZ), 823 dizygotic (DZ) and 19 unknown zygosity pairs) from a population-based Finnish Twin Cohort participated in a cross-sectional telephone assessment for dementia and in a single free recall trial of a 10-item word list. Results Cognitively healthy twins with demented co-twins (n=101 pairs) recalled less words than cognitively healthy twins with cognitively healthy co-twins (n=770 pairs) after adjusting for age, sex and education, B=-0.44, 95% C I (-0.73 to -0.14), p=0.003. The effect size was similar in MZ (n=31) twins (3.88 vs 4.29 words, B=-0.41, 95% C I (-0.96 to 0.13)) and DZ (n=66) twins (3.70 vs 4.17 words, B=-0.47, 95% C I (-0.84 to -0.10)). The heritability estimate of immediate recall (IR) was 0.37, 95% C I (0.21 to 0.43). Conclusions The results demonstrate that familial risk for dementia is reflected in the IR performance of cognitively healthy older persons. The finding of poorer IR performance in non-affected siblings compared with the general population, together with substantial heritability of IR, supports IR as a useful endophenotype for molecular genetic studies of dementia.
Subject: ALZHEIMERS-DISEASE
AMYLOID-BETA DEPOSITION
ASSOCIATION
CONVERSION
DECLINE
EPISODIC MEMORY
MILD COGNITIVE IMPAIRMENT
NEUROPSYCHOLOGICAL TESTS
PATTERNS
TRAJECTORIES
3112 Neurosciences
3124 Neurology and psychiatry
3126 Surgery, anesthesiology, intensive care, radiology
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