Association of the DBH Polymorphism rs3025343 With Smoking Cessation in a Large Population-Based Sample

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Hirvonen , K , Korhonen , T , Salomaa , V , Mannisto , S & Kaprio , J 2017 , ' Association of the DBH Polymorphism rs3025343 With Smoking Cessation in a Large Population-Based Sample ' , Nicotine & Tobacco Research , vol. 19 , no. 9 , pp. 1112-1115 . https://doi.org/10.1093/ntr/ntx066

Title: Association of the DBH Polymorphism rs3025343 With Smoking Cessation in a Large Population-Based Sample
Author: Hirvonen, Katariina; Korhonen, Tellervo; Salomaa, Veikko; Mannisto, Satu; Kaprio, Jaakko
Contributor organization: Institute for Molecular Medicine Finland
Clinicum
Department of Public Health
Jaakko Kaprio / Principal Investigator
University of Helsinki
Genetic Epidemiology
Date: 2017-09
Language: eng
Number of pages: 4
Belongs to series: Nicotine & Tobacco Research
ISSN: 1462-2203
DOI: https://doi.org/10.1093/ntr/ntx066
URI: http://hdl.handle.net/10138/311504
Abstract: Introduction: Genetic variations in DBH-gene and its surroundings have been shown to associate with smoking behavior including smoking cessation in several studies. In this study we replicate and measure the effect size for association between DBH polymorphism rs3025343 and smoking cessation in a large population-based sample while examining environmental factors that could relate to the association. Methods: We studied 11 926 adult subjects from four surveys of the National FINRISK Study. The analysis was restricted to either current or former smokers. Logistic and linear regression analyses were conducted to investigate the relationships of the single nucleotide polymorphism (SNP), covariates, smoking cessation, and smoking severity (cotinine, CPD). Gene-environment interactions were tested by likelihood-ratio test. Results: The association between rs3025343 and smoking cessation (prevalence odds ratio, OR = 1.12, p = .094, 95% CI = 0.98-1.30) was replicated identically with the GWAS study of The Tobacco and Genetics Consortium (OR = 1.12, 95% CI = 1.08-1.18). None of our tested phenotypes significantly influenced the association between rs3025343 and smoking cessation. Overall, marital status, education, depression, alcohol use, self-rated health, and chronic obstructive pulmonary disease (COPD) showed phenotypic associations with smoking cessation, but the association of various phenotypes with smoking cessation did not vary by genotype. Conclusions: The current study replicates the effect size for the association between rs3025343 and smoking cessation despite lack of overall significance due to smaller sample size. We could not show environmental influences on the association of rs3025343 with smoking cessation. Implications: Our study replicates the direction and strength of the association of DBH polymorphism rs3025343 with smoking cessation. We could not detect environmental influences on the strength of the association of rs3025343 with smoking cessation, but the limited power of our analysis needs to be taken into account.
Subject: BETA-HYDROXYLASE DBH
NICOTINE DEPENDENCE
GENETIC-VARIATION
SMOKERS
BEHAVIOR
3142 Public health care science, environmental and occupational health
Peer reviewed: Yes
Rights: unspecified
Usage restriction: openAccess
Self-archived version: acceptedVersion


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