Estrogenic Activities of Food Supplements and Beers as Assessed by a Yeast Bioreporter Assay

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http://hdl.handle.net/10138/311641

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Omoruyi , I M & Pohjanvirta , R 2018 , ' Estrogenic Activities of Food Supplements and Beers as Assessed by a Yeast Bioreporter Assay ' , Journal of Dietary Supplements , vol. 15 , no. 5 , pp. 665-672 . https://doi.org/10.1080/19390211.2017.1380104

Title: Estrogenic Activities of Food Supplements and Beers as Assessed by a Yeast Bioreporter Assay
Author: Omoruyi, I.M.; Pohjanvirta, R.
Contributor: University of Helsinki, Raimo Pohjanvirta / Principal Investigator
Date: 2018
Language: eng
Number of pages: 8
Belongs to series: Journal of Dietary Supplements
ISSN: 1939-0211
URI: http://hdl.handle.net/10138/311641
Abstract: Mounting evidence of the effects of endocrine-disrupting chemicals (EDCs) in humans has led to assaying a vast array of food items (processed or packaged) as possible sources of human exposure to estrogens. In this study, we investigated the current situation in this respect of different food supplements and beer brands. Eleven food supplements and 24 beer brands were obtained from Helsinki, Finland. Sample preparation was carried out by established methods while estrogenic activities were assessed by a yeast bioluminescent assay, using two recombinant yeast strains (Saccharomyces cerevisiae BMAEREluc/ERα and S. cerevisiae BMA64/luc). All the food supplements as well as 81% of the beer samples tested were found to be estrogenic, with estradiol equivalent concentrations of food supplements and beer brands ranging from 7.5 to 11.5 µg/ml and from below detection limits to 43.6 ng/ml, respectively. The estrogenic activities detected in beer samples were not dependent on the beer's alcoholic content, the country of production, or the size of the production brewery. The results of our study imply that both food supplements and beers can be a significant source of human exposure to estrogens. Therefore, further studies and regular surveillance are warranted. © 2018, © 2018 Taylor & Francis Group, LLC.
Subject: beer
bioassay
endocrine-disrupting chemicals
estrogenic activity
food supplements
isoflavones
isoxanthohumol
phytoestrogens
endocrine disruptor
estradiol
estrogen
phytoestrogen
analysis
dietary supplement
Finland
food analysis
human
luminescence
procedures
Saccharomyces cerevisiae
Beer
Biological Assay
Dietary Supplements
Endocrine Disruptors
Estradiol
Estrogens
Food Analysis
Humans
Luminescent Measurements
Phytoestrogens
416 Food Science
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