Inflammatory biomarkers in saliva and serum of patients with rheumatoid arthritis with respect to periodontal status

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Äyräväinen , L , Heikkinen , A M , Kuuliala , A , Ahola , K , Koivuniemi , R , Laasonen , L , Moilanen , E , Hämäläinen , M , Tervahartiala , T , Meurman , J H , Leirisalo-Repo , M & Sorsa , T 2018 , ' Inflammatory biomarkers in saliva and serum of patients with rheumatoid arthritis with respect to periodontal status ' , Annals of medicine , vol. 50 , no. 4 , pp. 333-344 . https://doi.org/10.1080/07853890.2018.1468922

Title: Inflammatory biomarkers in saliva and serum of patients with rheumatoid arthritis with respect to periodontal status
Author: Äyräväinen, Leena; Heikkinen, Anna Maria; Kuuliala, Antti; Ahola, Kirsi; Koivuniemi, Riitta; Laasonen, Leena; Moilanen, Eeva; Hämäläinen, Mari; Tervahartiala, Taina; Meurman, Jukka H.; Leirisalo-Repo, Marjatta; Sorsa, Timo
Contributor organization: Department of Oral and Maxillofacial Diseases
HUS Head and Neck Center
Clinicum
University of Helsinki
Department of Bacteriology and Immunology
Medicum
Helsinki University Hospital Area
Department of Medicine
Reumatologian yksikkö
HUS Inflammation Center
Department of Diagnostics and Therapeutics
HUS Medical Imaging Center
Timo Sorsa / Principal Investigator
Suu- ja leukakirurgian yksikkö
Date: 2018
Language: eng
Number of pages: 12
Belongs to series: Annals of medicine
ISSN: 0785-3890
DOI: https://doi.org/10.1080/07853890.2018.1468922
URI: http://hdl.handle.net/10138/311661
Abstract: Objective: To study prospectively the association of salivary and serum matrix metalloproteinase (MMP)-8, tissue inhibitor of MMPs (TIMP)-1 and interleukin (IL)-6 with periodontal and systemic inflammation in rheumatoid arthritis (RA). We hypothesized that biomarker concentrations reflect inflammation. Methods: Fifty three early untreated RA (ERA) and 28 chronic RA (CRA) patients, underwent rheumatological and dental examinations at baseline and one year later after starting first conventional or biological disease modifying antirheumatic drug. We included 43 control subjects. Saliva and serum samples were analyzed for MMP-8, TIMP-1 and IL-6. Periodontal health was assessed by bleeding on probing (BOP), pocket depth (PD) and periodontal inflammatory burden index (PIBI); RA disease activity was assessed by disease activity score DAS28. Joint destruction was analyzed by the modified Sharp-van der Heijde (SHS) method. Results: Serum MMP-8 (p <.001; p <.001) and IL-6 (p <.001; p =.002) were significantly higher in CRA vs. other study groups during the study. Salivary MMP-8 (p =.010) and IL-6 (p =.010) were significantly higher in ERA vs. other study groups at baseline. Salivary MMP-8 was associated with periodontal parameters. Conclusion: Elevated serum concentrations of MMP-8 and IL-6 in CRA patients reflected chronic RA, while elevated salivary concentrations of MMP-8 levels in ERA patients reflected increased periodontal inflammation.
Subject: Arthritis
rheumatoid
MMP-8
TIMP-1
IL-6
antirheumatic agents
periodontitis
MATRIX METALLOPROTEINASE-8
DISEASE-ACTIVITY
RESPONSE CRITERIA
CASE DEFINITIONS
SYNOVIAL-FLUID
INTERLEUKIN-6
POPULATION
HEALTH
TISSUE
3121 General medicine, internal medicine and other clinical medicine
313 Dentistry
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: acceptedVersion


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