Interplay between MicroRNAs and Oxidative Stress in Neurodegenerative Diseases

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Konovalova , J , Gerasymchuk , D , Parkkinen , I , Chmielarz , P & Domanskyi , A 2019 , ' Interplay between MicroRNAs and Oxidative Stress in Neurodegenerative Diseases ' , International Journal of Molecular Sciences , vol. 20 , no. 23 , 6055 . https://doi.org/10.3390/ijms20236055

Title: Interplay between MicroRNAs and Oxidative Stress in Neurodegenerative Diseases
Author: Konovalova, Julia; Gerasymchuk, Dmytro; Parkkinen, Ilmari; Chmielarz, Piotr; Domanskyi, Andrii
Other contributor: University of Helsinki, Institute of Biotechnology
University of Helsinki, Neuroscience Center
University of Helsinki, Polish Acad Sci, Polish Academy of Sciences, Maj Inst Pharmacol, Dept Brain Biochem
University of Helsinki, Institute of Biotechnology





Date: 2019-12
Language: eng
Number of pages: 26
Belongs to series: International Journal of Molecular Sciences
ISSN: 1422-0067
DOI: https://doi.org/10.3390/ijms20236055
URI: http://hdl.handle.net/10138/311662
Abstract: MicroRNAs are post-transcriptional regulators of gene expression, crucial for neuronal differentiation, survival, and activity. Age-related dysregulation of microRNA biogenesis increases neuronal vulnerability to cellular stress and may contribute to the development and progression of neurodegenerative diseases. All major neurodegenerative disorders are also associated with oxidative stress, which is widely recognized as a potential target for protective therapies. Albeit often considered separately, microRNA networks and oxidative stress are inextricably entwined in neurodegenerative processes. Oxidative stress affects expression levels of multiple microRNAs and, conversely, microRNAs regulate many genes involved in an oxidative stress response. Both oxidative stress and microRNA regulatory networks also influence other processes linked to neurodegeneration, such as mitochondrial dysfunction, deregulation of proteostasis, and increased neuroinflammation, which ultimately lead to neuronal death. Modulating the levels of a relatively small number of microRNAs may therefore alleviate pathological oxidative damage and have neuroprotective activity. Here, we review the role of individual microRNAs in oxidative stress and related pathways in four neurodegenerative conditions: Alzheimer's (AD), Parkinson's (PD), Huntington's (HD) disease, and amyotrophic lateral sclerosis (ALS). We also discuss the problems associated with the use of oversimplified cellular models and highlight perspectives of studying microRNA regulation and oxidative stress in human stem cell-derived neurons.
Subject: microRNA
oxidative stress
ROS
translation regulation
neurodegeneration
Alzheimer's disease
Parkinson's disease
Huntington's disease
ALS
ALPHA-SYNUCLEIN EXPRESSION
PROMOTES TAU PHOSPHORYLATION
AMYLOID PRECURSOR PROTEIN
PARKINSONS-DISEASE
HUNTINGTONS-DISEASE
ALZHEIMERS-DISEASE
DOPAMINE TRANSPORTER
DOWN-REGULATION
MIRNA BIOGENESIS
DICER EXPRESSION
1182 Biochemistry, cell and molecular biology
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