Tracting the neural basis of music : Deficient structural connectivity underlying acquired amusia

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http://hdl.handle.net/10138/311677

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Sihvonen , A J , Ripolles , P , Särkämö , T , Leo , V , Rodriguez-Fornells , A , Saunavaara , J , Parkkola , R & Soinila , S 2017 , ' Tracting the neural basis of music : Deficient structural connectivity underlying acquired amusia ' , Cortex , vol. 97 , pp. 255-273 . https://doi.org/10.1016/j.cortex.2017.09.028

Title: Tracting the neural basis of music : Deficient structural connectivity underlying acquired amusia
Author: Sihvonen, Aleksi J.; Ripolles, Pablo; Särkämö, Teppo; Leo, Vera; Rodriguez-Fornells, Antoni; Saunavaara, Jani; Parkkola, Riitta; Soinila, Seppo
Contributor: University of Helsinki, Cognitive Brain Research Unit
University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, HUS Neurocenter
Date: 2017-12-08
Number of pages: 19
Belongs to series: Cortex
ISSN: 0010-9452
URI: http://hdl.handle.net/10138/311677
Abstract: Acquired amusia provides a unique opportunity to investigate the fundamental neural architectures of musical processing due to the transition from a functioning to defective music processing system. Yet, the white matter (WM) deficits in amusia remain systematically unexplored. To evaluate which WM structures form the neural basis for acquired amusia and its recovery, we studied 42 stroke patients longitudinally at acute, 3-month, and 6-month post-stroke stages using DTI [tract-based spatial statistics (TBSS) and deterministic tractography (DT)] and the Scale and Rhythm subtests of the Montreal Battery of Evaluation of Amusia (MBEA). Non-recovered amusia was associated with structural damage and subsequent degeneration in multiple WM tracts including the right inferior fronto-occipital fasciculus (IFOF), arcuate fasciculus (AF), inferior longitudinal fasciculus (ILF), uncinate fasciculus (UF), and frontal aslant tract (FAT), as well as in the corpus callosum (CC) and its posterior part (tapetum). In a linear regression analysis, the volume of the right IFOF was the main predictor of MBEA performance across time. Overall, our results provide a comprehensive picture of the large-scale deficits in intra- and interhemispheric structural connectivity underlying amusia, and conversely highlight which pathways are crucial for normal music perception.
Subject: 3124 Neurology and psychiatry
515 Psychology
amusia
MUSIC
STROKE
TRACTOGRAPHY
Tract-based spatial statistics
FUNCTIONAL MRI EVIDENCE
CONGENITAL AMUSIA
WHITE-MATTER
AUDITORY-CORTEX
ARCUATE FASCICULUS
HUMAN BRAIN
UNCINATE FASCICULUS
DTI tractography
CORPUS-CALLOSUM
anatomic dissection
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