Tracting the neural basis of music : Deficient structural connectivity underlying acquired amusia

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dc.contributor.author Sihvonen, Aleksi J.
dc.contributor.author Ripolles, Pablo
dc.contributor.author Särkämö, Teppo
dc.contributor.author Leo, Vera
dc.contributor.author Rodriguez-Fornells, Antoni
dc.contributor.author Saunavaara, Jani
dc.contributor.author Parkkola, Riitta
dc.contributor.author Soinila, Seppo
dc.date.accessioned 2020-02-14T12:27:01Z
dc.date.available 2020-02-14T12:27:01Z
dc.date.issued 2017-12-08
dc.identifier.citation Sihvonen , A J , Ripolles , P , Särkämö , T , Leo , V , Rodriguez-Fornells , A , Saunavaara , J , Parkkola , R & Soinila , S 2017 , ' Tracting the neural basis of music : Deficient structural connectivity underlying acquired amusia ' , Cortex , vol. 97 , pp. 255-273 . https://doi.org/10.1016/j.cortex.2017.09.028
dc.identifier.other PURE: 94958242
dc.identifier.other PURE UUID: 0e3b9c98-cf87-40fa-9738-9e966e36c145
dc.identifier.other Scopus: 85032973284
dc.identifier.other WOS: 000418987100020
dc.identifier.other ORCID: /0000-0003-2638-9918/work/40901541
dc.identifier.uri http://hdl.handle.net/10138/311677
dc.description.abstract Acquired amusia provides a unique opportunity to investigate the fundamental neural architectures of musical processing due to the transition from a functioning to defective music processing system. Yet, the white matter (WM) deficits in amusia remain systematically unexplored. To evaluate which WM structures form the neural basis for acquired amusia and its recovery, we studied 42 stroke patients longitudinally at acute, 3-month, and 6-month post-stroke stages using DTI [tract-based spatial statistics (TBSS) and deterministic tractography (DT)] and the Scale and Rhythm subtests of the Montreal Battery of Evaluation of Amusia (MBEA). Non-recovered amusia was associated with structural damage and subsequent degeneration in multiple WM tracts including the right inferior fronto-occipital fasciculus (IFOF), arcuate fasciculus (AF), inferior longitudinal fasciculus (ILF), uncinate fasciculus (UF), and frontal aslant tract (FAT), as well as in the corpus callosum (CC) and its posterior part (tapetum). In a linear regression analysis, the volume of the right IFOF was the main predictor of MBEA performance across time. Overall, our results provide a comprehensive picture of the large-scale deficits in intra- and interhemispheric structural connectivity underlying amusia, and conversely highlight which pathways are crucial for normal music perception. fi
dc.format.extent 19
dc.language.iso eng
dc.relation.ispartof Cortex
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject 3124 Neurology and psychiatry
dc.subject 515 Psychology
dc.subject amusia
dc.subject MUSIC
dc.subject STROKE
dc.subject TRACTOGRAPHY
dc.subject Tract-based spatial statistics
dc.subject FUNCTIONAL MRI EVIDENCE
dc.subject CONGENITAL AMUSIA
dc.subject WHITE-MATTER
dc.subject AUDITORY-CORTEX
dc.subject ARCUATE FASCICULUS
dc.subject HUMAN BRAIN
dc.subject UNCINATE FASCICULUS
dc.subject DTI tractography
dc.subject CORPUS-CALLOSUM
dc.subject anatomic dissection
dc.title Tracting the neural basis of music : Deficient structural connectivity underlying acquired amusia en
dc.type Article
dc.contributor.organization Cognitive Brain Research Unit
dc.contributor.organization Department of Psychology and Logopedics
dc.contributor.organization Medicum
dc.contributor.organization Teija Kujala Research Group
dc.contributor.organization HUS Neurocenter
dc.contributor.organization Brain, Music and Learning
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.cortex.2017.09.028
dc.relation.issn 0010-9452
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion

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