Presentation of second primary cancers in young laryngeal carcinoma patients

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http://hdl.handle.net/10138/311685

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Silen , S , Haapaniemi , A , Dickinson , A , Rönn , K & Mäkitie , A 2019 , ' Presentation of second primary cancers in young laryngeal carcinoma patients ' , Acta Oto-Laryngologica , vol. 139 , no. 1 , pp. 85-89 . https://doi.org/10.1080/00016489.2018.1527037

Title: Presentation of second primary cancers in young laryngeal carcinoma patients
Author: Silen, Suvi; Haapaniemi, Aaro; Dickinson, Amy; Rönn, Karin; Mäkitie, Antti
Contributor: University of Helsinki, Department of Surgery
University of Helsinki, Clinicum
University of Helsinki, Department of Ophthalmology and Otorhinolaryngology
Date: 2019-01-02
Number of pages: 5
Belongs to series: Acta Oto-Laryngologica
ISSN: 0001-6489
URI: http://hdl.handle.net/10138/311685
Abstract: Background: Laryngeal squamous cell carcinoma (LSCC) is rare in the young. Objectives: We characterized the clinical behavior of LSCC and assessed the presentation of second primary tumors (SPCs) in this patient population. Materials and methods: Data from the Finnish Cancer Registry (FCR) were used to identify an epidemiological series of LSCC patients diagnosed at the age of 40 years or under, during 1953-2012 in Finland. Data regarding primary treatment, survival, and SPCs were available. To further characterize the comorbidity and lifestyle factors of young patients with LSCC, institutional data were collected of patients treated at the Helsinki University Hospital during 1967-2012. Results: We identified 151 patients, with a mean follow-up of 252 months. The 10-year overall survival (OS) was 75% and the disease-specific survival was 84%. SPCs were diagnosed in 26% (n = 39), with a median delay of 28 years. Of the 35 patients in the institutional series from Helsinki, 22 (63%) were current or former smokers. LSCC recurred in 28% of patients. Conclusions and Significance: The delay to SPCs in young patients was significantly longer compared with the general LSCC population. As factors underlying this phenomenon cannot be identified by this retrospective study, further studies are warranted.
Subject: Squamous cell carcinoma
survival
laryngeal cancer
young patients
risk factors
second primary cancer
recurrence
SQUAMOUS-CELL CARCINOMA
RISK
HEAD
SURVIVAL
AGE
3125 Otorhinolaryngology, ophthalmology
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