Intergenerational Transmission of Birth Weight Across 3 Generations

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http://hdl.handle.net/10138/311687

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Lahti-Pulkkinen , M , Bhattacharya , S , Räikkönen , K , Osmond , C , Norman , J E & Reynolds , R M 2018 , ' Intergenerational Transmission of Birth Weight Across 3 Generations ' , American Journal of Epidemiology , vol. 187 , no. 6 , pp. 1165-1173 . https://doi.org/10.1093/aje/kwx340

Title: Intergenerational Transmission of Birth Weight Across 3 Generations
Author: Lahti-Pulkkinen, Marius; Bhattacharya, Sohinee; Räikkönen, Katri; Osmond, Clive; Norman, Jane E.; Reynolds, Rebecca M.
Contributor: University of Helsinki, Medicum
University of Helsinki, Medicum
Date: 2018-06
Number of pages: 9
Belongs to series: American Journal of Epidemiology
ISSN: 0002-9262
URI: http://hdl.handle.net/10138/311687
Abstract: While previous studies have shown intergenerational transmission of birth weight from mother to child, whether the continuity persists across 3 generations has rarely been assessed. We used the Aberdeen Maternity and Neonatal Data-bank (United Kingdom) to examine the intergenerational correlations of birth weight, birth weight adjusted for gestational age and sex, and small- and large-for-gestational-age births across 3 generations among 1,457 grandmother-mother-child triads. All participants were born between 1950 and 2015. The intergenerational transmission was examined with linear regression analyses. We found that grandmaternal birth weight was associated with grandchild birth weight, independently of prenatal and sociodemographic covariates and maternal birth weight (B = 0.12 standard deviation units, 95% confidence interval: 0.07, 0.18). Similar intergenerational continuity was found for birth weight adjusted for sex and gestational age as well as for small-for-gestational-age births. In conclusion, birth weight and fetal growth showed intergenerational continuity across 3 generations. This supports the hypothesis that the developmental origins of birth weight and hence later health and disease are already present in earlier generations.
Subject: birth weight
cross-generational
fetal growth
grandchild
grandmaternal
longitudinal
small for gestational age
FOR-GESTATIONAL-AGE
MIDDLE-INCOME COUNTRIES
DIABETES-MELLITUS
PRETERM BIRTH
COHORT
METAANALYSIS
GROWTH
RISK
WOMEN
CHILD
515 Psychology
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