Social isolation and loneliness as risk factors for myocardial infarction, stroke and mortality : UK Biobank cohort study of 479 054 men and women

Show full item record



Permalink

http://hdl.handle.net/10138/311737

Citation

Hakulinen , C , Pulkki-Råback , L , Virtanen , M , Jokela , M , Kivimäki , M & Elovainio , M 2018 , ' Social isolation and loneliness as risk factors for myocardial infarction, stroke and mortality : UK Biobank cohort study of 479 054 men and women ' , Heart , vol. 104 , no. 18 , pp. 1536-1542 . https://doi.org/10.1136/heartjnl-2017-312663

Title: Social isolation and loneliness as risk factors for myocardial infarction, stroke and mortality : UK Biobank cohort study of 479 054 men and women
Author: Hakulinen, Christian; Pulkki-Råback, Laura; Virtanen, Marianna; Jokela, Markus; Kivimäki, Mika; Elovainio, Marko
Contributor: University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, Clinicum
University of Helsinki, Medicum
Date: 2018-09
Language: eng
Number of pages: 7
Belongs to series: Heart
ISSN: 1355-6037
URI: http://hdl.handle.net/10138/311737
Abstract: Objective To examine whether social isolation and loneliness (1) predict acute myocardial infarction (AMI) and stroke among those with no history of AMI or stroke, (2) are related to mortality risk among those with a history of AMI or stroke, and (3) the extent to which these associations are explained by known risk factors or pre-existing chronic conditions. Methods Participants were 479 054 individuals from the UK Biobank. The exposures were self-reported social isolation and loneliness. AMI, stroke and mortality were the outcomes. Results Over 7.1 years, 5731 had first AMI, and 3471 had first stroke. In model adjusted for demographics, social isolation was associated with higher risk of AMI (HR 1.43, 95% CI 1.3 to -1.55) and stroke (HR 1.39, 95% CI 1.25 to 1.54). When adjusted for all the other risk factors, the HR for AMI was attenuated by 84% to 1.07 (95% CI 0.99 to 1.16) and the HR for stroke was attenuated by 83% to 1.06 (95% CI 0.96 to 1.19). Loneliness was associated with higher risk of AMI before (HR 1.49, 95% CI 1.36 to 1.64) but attenuated considerably with adjustments (HR 1.06, 95% CI 0.96 to 1.17). This was also the case for stroke (HR 1.36, 95% CI 1.20 to 1.55 before and HR 1.04, 95% CI 0.91 to 1.19 after adjustments). Social isolation, but not loneliness, was associated with increased mortality in participants with a history of AMI (HR 1.25, 95% CI 1.03 to 1.51) or stroke (HR 1.32, 95% CI 1.08 to 1.61) in the fully adjusted model. Conclusions Isolated and lonely persons are at increased risk of AMI and stroke, and, among those with a history of AMI or stroke, increased risk of death. Most of this risk was explained by conventional risk factors.
Subject: CORONARY-HEART-DISEASE
ASSOCIATION
METAANALYSIS
PROGNOSIS
SUPPORT
UPDATE
SCALE
3121 General medicine, internal medicine and other clinical medicine
515 Psychology
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
Hakulinen_et_al_2018_HEART_accepted_1_.pdf 505.3Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record