Other Primary Malignancies Among Women With Adult-Type Ovarian Granulosa Cell Tumors

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Bryk , S , Pukkala , E , Färkkilä , A , Heikinheimo , M , Unkila-Kallio , L & Riska , A 2018 , ' Other Primary Malignancies Among Women With Adult-Type Ovarian Granulosa Cell Tumors ' , International Journal of Gynecological Cancer , vol. 28 , no. 8 , pp. 1529-1534 . https://doi.org/10.1097/IGC.0000000000001333

Title: Other Primary Malignancies Among Women With Adult-Type Ovarian Granulosa Cell Tumors
Author: Bryk, Saara; Pukkala, Eero; Färkkilä, Anniina; Heikinheimo, Markku; Unkila-Kallio, Leila; Riska, Annika
Contributor organization: Developmental and tumor biology research group
Children's Hospital
Department of Obstetrics and Gynecology
HUS Gynecology and Obstetrics
HUS Children and Adolescents
Date: 2018-10
Language: eng
Number of pages: 6
Belongs to series: International Journal of Gynecological Cancer
ISSN: 1048-891X
DOI: https://doi.org/10.1097/IGC.0000000000001333
URI: http://hdl.handle.net/10138/311747
Abstract: Objective: The aim of this study was to determine the incidence of new primary malignancies after adult-type granulosa cell tumor (AGCT) and the incidence of AGCT after breast and uterine cancer using nationwide population-based registry data. Methods: We used the Finnish Cancer Registry to identify all patients diagnosed with AGCT in 1968 to 2013 (n = 986). The number of subsequent primary malignancies among women with AGCT and the number of AGCTs in women with previous breast or uterine cancer were compared with the expected number of cases and expressed as standardized incidence ratios (SIRs). Results: There were 122 cases of subsequent cancers diagnosed at least 6 months after the primary diagnosis of AGCT (SIR, 1.09; 95% confidence interval [CI], 0.91-1.3). In particular, the observed number of cancers of the soft tissue (SIR, 4.13; 95% CI, 1.33-12.8), thyroid (SIR, 3.42; 95% CI, 1.54-7.62), and leukemia (SIR, 2.67; 95% CI, 0.98-5.82) exceeded the number of expected cases. The SIR for breast cancers after AGCT was 1.26 (95% CI, 0.92-1.73), and the SIR for AGCT after breast cancer was 1.59 (95% CI, 1.04-2.29). The risk for subsequent AGCT was more than 2-fold in breast cancer patients younger than 50 years, and over 15 years after primary diagnosis. Conclusions: There is an increased risk for thyroid and soft tissue cancer as well as leukemia after AGCT, which may be associated with late effects of carcinogenic treatments and possibly shared risk factors. After breast cancer, the risk for AGCT was higher, which may indicate a shared hormonal etiology.
Subject: Granulosa cell tumor
Sex cord-stromal tumors
Second primary malignancy
Second primary cancer
Ovarian cancer epidemiology
3122 Cancers
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Rights: cc_by_nc
Usage restriction: openAccess
Self-archived version: acceptedVersion

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