Non-invasive vagus nerve stimulation reduces sympathetic preponderance in patients with tinnitus

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Ylikoski , J , Lehtimaki , J , Pirvola , U , Makitie , A , Aarnisalo , A , Hyvarinen , P & Ylikoski , M 2017 , ' Non-invasive vagus nerve stimulation reduces sympathetic preponderance in patients with tinnitus ' , Acta Oto-Laryngologica , vol. 137 , no. 4 , pp. 426-431 . https://doi.org/10.1080/00016489.2016.1269197

Title: Non-invasive vagus nerve stimulation reduces sympathetic preponderance in patients with tinnitus
Author: Ylikoski, Jukka; Lehtimaki, Jarmo; Pirvola, Ulla; Makitie, Antti; Aarnisalo, Antti; Hyvarinen, Petteri; Ylikoski, Matti
Contributor organization: Biosciences
Clinicum
Korva-, nenä- ja kurkkutautien klinikka
HUS Head and Neck Center
Date: 2017
Language: eng
Number of pages: 6
Belongs to series: Acta Oto-Laryngologica
ISSN: 0001-6489
DOI: https://doi.org/10.1080/00016489.2016.1269197
URI: http://hdl.handle.net/10138/311765
Abstract: Conclusion: Transcutaneous vagal nerve stimulation (tVNS) might offer a targeted, patient-friendly, and low-cost therapeutic tool for tinnitus patients with sympathovagal imbalance. Objectives: Conventionally, VNS has been performed to treat severe epilepsy and depression with an electrode implanted to the cervical trunk of vagus nerve. This study investigated the acute effects of tVNS on autonomic nervous system (ANS) imbalance, which often occurs in patients with tinnitus-triggered stress. Methods: This study retrospectively analysed records of 97 patients who had undergone ANS function testing by heart rate variability (HRV) measurement immediately before and after a 15-60min tVNS stimulation. Results: The pre-treatment HRV recording showed sympathetic preponderance/reduced parasympathetic activity in about three quarters (73%) of patients. Active tVNS significantly increased variability of R-R intervals in 75% of patients and HRV age was decreased in 70% of patients. Either the variability of R-R intervals was increased or the HRV age decreased in 90% of the patients. These results indicate that tVNS can induce a shift in ANS function from sympathetic preponderance towards parasympathetic predominance. tVNS caused no major morbidity, and heart rate monitoring during the tVNS treatment showed no cardiac or circulatory effects (e.g. bradycardia) in any of the patients.
Subject: Stress
heart rate variability
autonomic nervous system
tinnitus
vagal nerve
HEART-RATE-VARIABILITY
3125 Otorhinolaryngology, ophthalmology
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: acceptedVersion


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