Functionalized lipids and surfactants for specific applications

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Kepczynski , M & Rog , T 2016 , ' Functionalized lipids and surfactants for specific applications ' , Biochimica et Biophysica Acta. Biomembranes , vol. 1858 , no. 10 , pp. 2362-2379 . https://doi.org/10.1016/j.bbamem.2016.02.038

Title: Functionalized lipids and surfactants for specific applications
Author: Kepczynski, Mariusz; Rog, Tomasz
Other contributor: University of Helsinki, Department of Physics
Date: 2016-10
Language: eng
Number of pages: 18
Belongs to series: Biochimica et Biophysica Acta. Biomembranes
ISSN: 0005-2736
DOI: https://doi.org/10.1016/j.bbamem.2016.02.038
URI: http://hdl.handle.net/10138/311777
Abstract: Synthetic lipids and surfactants that do not exist in biological systems have been used for the last few decades in both basic and applied science. The most notable applications for synthetic lipids and surfactants are drug delivery, gene transfection, as reporting molecules, and as support for structural lipid biology. In this review, we describe the potential of the synergistic combination of computational and experimental methodologies to study the behavior of synthetic lipids and surfactants embedded in lipid membranes and liposomes. We focused on select cases in which molecular dynamics simulations were used to complement experimental studies aiming to understand the structure and properties of new compounds at the atomistic level. We also describe cases in which molecular dynamics simulations were used to design new synthetic lipids and surfactants, as well as emerging fields for the application of these compounds. This article is part of a Special Issue entitled: Biosimulations edited by Ilpo Vattulainen and Tomasz Rog. (C) 2016 Elsevier B.V. All rights reserved.
Subject: Synthetic lipid
Molecular dynamics simulation
Cholesterol
Sphingomyelin
Drug delivery
Reporting molecule
MOLECULAR-DYNAMICS SIMULATION
SPIN-LABELED PHOSPHOLIPIDS
INVERSE-PHOSPHOCHOLINE LIPIDS
SPHINGOMYELIN HEADGROUP SIZE
THERMOTROPIC PHASE-BEHAVIOR
LIPOSOMAL DRUG-DELIVERY
ATOM FORCE-FIELD
OF-THE-ART
BILAYER-MEMBRANES
CHOLESTERYL HEMISUCCINATE
1182 Biochemistry, cell and molecular biology
114 Physical sciences
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