Self and Informant Memory Reports in FINGER : Associations with Two-Year Cognitive Change

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http://hdl.handle.net/10138/311830

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Vaskivuo , L , Hokkanen , L , Hänninen , T , Antikainen , R , Bäckman , L , Laatikainen , T , Paajanen , T , Stigsdotter-Neely , A , Strandberg , T , Tuomilehto , J , Soininen , H , Kivipelto , M & Ngandu , T 2019 , ' Self and Informant Memory Reports in FINGER : Associations with Two-Year Cognitive Change ' , Journal of Alzheimer's Disease , vol. 71 , no. 3 , pp. 785-795 . https://doi.org/10.3233/JAD-190133

Title: Self and Informant Memory Reports in FINGER : Associations with Two-Year Cognitive Change
Author: Vaskivuo, Laura; Hokkanen, Laura; Hänninen, Tuomo; Antikainen, Riitta; Bäckman, Lars; Laatikainen, Tiina; Paajanen, Teemu; Stigsdotter-Neely, Anna; Strandberg, Timo; Tuomilehto, Jaakko; Soininen, Hilkka; Kivipelto, Miia; Ngandu, Tiia
Contributor: University of Helsinki, Department of Psychology and Logopedics
University of Helsinki, Department of Psychology and Logopedics
University of Helsinki, HUS Internal Medicine and Rehabilitation
University of Helsinki, Clinicum
Date: 2019
Language: eng
Number of pages: 11
Belongs to series: Journal of Alzheimer's Disease
ISSN: 1387-2877
URI: http://hdl.handle.net/10138/311830
Abstract: Background:Subjective memory complaints (SMCs) may be the first sign of cognitive decline in aging. Objective:To examine whether SMCs reported by oneself and informant predict cognitive change over 2 years among at-risk elderly people, and to determine the relationship of different types of SMCs (prospective and retrospective memory complaints) and change in cognitive function. Methods:This investigation is part of the FINGER project, which is a multicenter randomized controlled trial aiming at preventing cognitive decline in cognitively healthy older adults with increased risk of dementia. A subsample of 303 control-group participants (aged 60–80 years) and their informants (n = 261) rated the frequency of SMCs, using the Prospective and Retrospective Memory Questionnaire (PRMQ). Cognitive performance was measured at baseline and at 1- and 2-year follow-up visits using a neuropsychological test battery. Results:Participants who reported more SMCs improved less in global cognition, executive function, and memory during the subsequent 2 years in the fully-adjusted analyses. Self-reported retrospective memory problems predicted less improvement in all cognitive domains, whereas prospective memory problems did not. Informant-reported memory problems were not linked to subsequent change in cognition. Conclusion:Our results indicate that self-reported SMCs, measured with PRMQ, predict future cognitive change in several cognitive domains. By contrast, reports by informants were not linked to changes in cognition. Among cognitively healthy at-risk elderly individuals, the persons themselves observe more easily problems relevant for their future cognitive trajectories than their informants.
Subject: Aging
cognition
dementia
memory
PRECLINICAL ALZHEIMERS-DISEASE
FINNISH GERIATRIC INTERVENTION
HEALTHY OLDER-ADULTS
MINI-MENTAL-STATE
RETROSPECTIVE MEMORY
NORMATIVE DATA
DEPRESSIVE SYMPTOMS
QUESTIONNAIRE PRMQ
LATENT STRUCTURE
RISK-FACTORS
515 Psychology
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