Tumor expression of human chorionic gonadotropin beta mRNA and prognosis of prostate cancer treated by radical prostatectomy

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http://hdl.handle.net/10138/311848

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Lintula , S , Mirtti , T , Rannikko , A , Bützow , A , Lempiäinen , A , Stenman , J , Stenman , U-H & Hotakainen , K 2019 , ' Tumor expression of human chorionic gonadotropin beta mRNA and prognosis of prostate cancer treated by radical prostatectomy ' , Scandinavian Journal of Clinical & Laboratory Investigation , vol. 79 , no. 6 , pp. 424-430 . https://doi.org/10.1080/00365513.2019.1639214

Title: Tumor expression of human chorionic gonadotropin beta mRNA and prognosis of prostate cancer treated by radical prostatectomy
Author: Lintula, Susanna; Mirtti, Tuomas; Rannikko, Antti; Bützow, Anna; Lempiäinen, Anna; Stenman, Jakob; Stenman, Ulf-Hakan; Hotakainen, Kristina
Contributor organization: Department of Clinical Chemistry and Hematology
University of Helsinki
Research Program in Systems Oncology
University Management
HUSLAB
Department of Pathology
Institute for Molecular Medicine Finland
Department of Surgery
Urologian yksikkö
HUS Abdominal Center
Staff Services
Medicum
Päivi Hotakainen / Principal Investigator
Date: 2019-08-18
Language: eng
Number of pages: 7
Belongs to series: Scandinavian Journal of Clinical & Laboratory Investigation
ISSN: 0036-5513
DOI: https://doi.org/10.1080/00365513.2019.1639214
URI: http://hdl.handle.net/10138/311848
Abstract: The beta subunit of human chorionic gonadotropin (hCG beta) is encoded by six genes (CGB) classified as type I and type II. CGB mRNA is produced in large amounts by trophoblastic tissues and in small amounts by several cancerous tissues including prostate cancer and by a few benign tissues, including the prostate. Quantitative reverse-transcription polymerase chain reaction (RT-qPCR) was used to study the expression levels of all CGB mRNAs together (total CGB mRNA) and the two types of CGB mRNA separately in non-cancerous (n = 74) and cancerous prostatic tissue obtained by radical prostatectomy (n = 193). RNA was isolated from formalin-fixed paraffin-embedded (FFPE) samples and mRNA levels of CGB were correlated with disease-specific survival. Total CGB mRNA concentrations were significantly lower (p <.0001) in cancerous than non-cancerous prostatic tissue. Separate analysis of type I CGB and type II CGB mRNA showed that both type I CGB (p <.0001) and type II CGB mRNA (p = .007) are lower in cancerous tissue than in non-cancerous tissue. Low type II CGB mRNA level in cancerous tissue was associated with shorter cancer-specific survival (p = .001) of prostate cancer patients treated by radical prostatectomy.
Subject: Human
chorionic gonadotropin beta
expression
prostate
cancer
CELL CARCINOMA
HCG-BETA
SUBUNIT GENES
URINARY CELLS
BLADDER
TRANSCRIPTION
SERUM
MARKER
TISSUE
3111 Biomedicine
Peer reviewed: Yes
Rights: unspecified
Usage restriction: openAccess
Self-archived version: acceptedVersion


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