Presenting symptoms and clinical findings in HPV-positive and HPV-negative oropharyngeal cancer patients

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Carpen , T , Sjöblom , A , Lundberg , M , Haglund , C , Markkola , A , Syrjänen , S , Tarkkanen , J , Mäkitie , A , Hagström , J & Mattila , P 2018 , ' Presenting symptoms and clinical findings in HPV-positive and HPV-negative oropharyngeal cancer patients ' , Acta Oto-Laryngologica , vol. 138 , no. 5 , pp. 513-518 . https://doi.org/10.1080/00016489.2017.1405279

Title: Presenting symptoms and clinical findings in HPV-positive and HPV-negative oropharyngeal cancer patients
Author: Carpen, Timo; Sjöblom, Anni; Lundberg, Marie; Haglund, Caj; Markkola, Antti; Syrjänen, Stina; Tarkkanen, Jussi; Mäkitie, Antti; Hagström, Jaana; Mattila, Petri
Contributor: University of Helsinki, Department of Ophthalmology and Otorhinolaryngology
University of Helsinki, HUSLAB
University of Helsinki, Korva-, nenä- ja kurkkutautien klinikka
University of Helsinki, Clinicum
University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Medicum
University of Helsinki, Korva-, nenä- ja kurkkutautien klinikka
Date: 2018
Language: eng
Number of pages: 6
Belongs to series: Acta Oto-Laryngologica
ISSN: 0001-6489
URI: http://hdl.handle.net/10138/311877
Abstract: Objectives: Oropharyngeal squamous cell carcinoma (OPSCC) is divided in two different disease entities depending on HPV involvement. We investigated differences in presenting symptoms and clinical findings in patients with HPV-positive and -negative OPSCC tumors. Methods: Altogether 118 consecutive patients diagnosed with primary OPSCC between 2012 and 2014 at the Helsinki University Hospital were included. HPV-status of the tumors was assessed by PCR detection of HPV DNA and immunostaining with p16-INK4a antibody. Results: Fifty-one (47.7%) of the patients had HPV-positive and 56 (52.3%) HPV-negative tumors. Forty-nine (49/51, 96.1%) of the HPV+ tumors were also p16+ showing high concordance. The most common presenting symptom among HPV+/p16+ patients was a neck mass (53.1%), whereas any sort of pain in the head and neck area was more frequently related to the HPV-/p16- (60.0%) group. HPV+/p16+ tumors had a tendency to locate in the tonsillar complex and more likely had already spread into regional lymph nodes compared with HPV-/p16- tumors. Smoking and heavy alcohol consumption were significantly more common among HPV-/p16- patients but also rather common among HPV+/p16+ patients. Conclusions: This analysis of symptoms and signs confirm that OPSCC can be dichotomized in two distinct disease entities as defined by HPV status.
Subject: Human papillomavirus
oropharynx
p16
symptom
cancer
etiology
SQUAMOUS-CELL CARCINOMA
HUMAN-PAPILLOMAVIRUS INFECTION
NECK CANCERS
RISK-FACTOR
HEAD
SURVIVAL
METAANALYSIS
DIAGNOSIS
3125 Otorhinolaryngology, ophthalmology
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