Workplace Diesel Exhausts and Gasoline Exposure and Risk of Colorectal Cancer in Four Nordic Countries

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http://hdl.handle.net/10138/311880

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Talibov , M , Sormunen , O , Weiderpass , E , Kjaerheim , K , Martinsen , J-I , Sparen , P , Tryggvadottir , L , Hansen , J & Pukkala , E 2019 , ' Workplace Diesel Exhausts and Gasoline Exposure and Risk of Colorectal Cancer in Four Nordic Countries ' , Safety and Health at Work , vol. 10 , no. 2 , pp. 141-150 . https://doi.org/10.1016/j.shaw.2019.01.001

Title: Workplace Diesel Exhausts and Gasoline Exposure and Risk of Colorectal Cancer in Four Nordic Countries
Author: Talibov, Madar; Sormunen, Orma; Weiderpass, Elisabete; Kjaerheim, Kristina; Martinsen, Jan-Ivar; Sparen, Per; Tryggvadottir, Laufey; Hansen, Johnni; Pukkala, Eero
Contributor organization: Department of Medical and Clinical Genetics
Faculty of Medicine
University of Helsinki
Date: 2019-06
Language: eng
Number of pages: 10
Belongs to series: Safety and Health at Work
ISSN: 2093-7911
DOI: https://doi.org/10.1016/j.shaw.2019.01.001
URI: http://hdl.handle.net/10138/311880
Abstract: Background: Evidence on associations between occupational diesel exhaust and gasoline exposure and colorectal cancer is limited. We aimed to assess the effect of workplace exposure to diesel exhaust and gasoline on the risk of colorectal cancer. Methods: This case-control study included 181,709 colon cancer and 109,227 rectal cancer cases diagnosed between 1961 and 2005 in Finland, Iceland, Norway, and Sweden. Cases and controls were identified from the Nordic Occupational Cancer Study cohort and matched for country, birth year, and sex. Diesel exhaust and gasoline exposure values were assigned by country-specific job-exposure matrices. Odds ratios and 95% confidence intervals were calculated by using conditional logistic regression models. The results were adjusted for physical strain at work and occupational exposure to benzene, formaldehyde, ionizing radiation, chlorinated hydrocarbons, chromium, and wood dust. Results: Diesel exhaust exposure was associated with a small increase in the risk of rectal cancer (odds ratio = 1.05, 95% confidence interval 1.02-1.08). Gasoline exposure was not associated with colorectal cancer risk. Conclusion: This study showed a small risk increase for rectal cancer after workplace diesel exhaust exposure. However, this finding could be due to chance, given the limitations of the study. (C) 2019 Occupational Safety and Health Research Institute, Published by Elsevier Korea LLC.
Subject: Case-control study
Colorectal cancer
Diesel exhaust
Gasoline
Workplace
OCCUPATIONAL-CANCER
RECTAL-CANCER
COLON
WORK
COHORT
HEALTH
RATS
3142 Public health care science, environmental and occupational health
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion


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