Whole blood microRNA levels associate with glycemic status and correlate with target mRNAs in pathways important to type 2 diabetes

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dc.contributor.author Mononen, Nina
dc.contributor.author Lyytikäinen, Leo-Pekka
dc.contributor.author Seppälä, Ilkka
dc.contributor.author Mishra, Pashupati P.
dc.contributor.author Juonala, Markus
dc.contributor.author Waldenberger, Melanie
dc.contributor.author Klopp, Norman
dc.contributor.author Illig, Thomas
dc.contributor.author Leiviskä, Jaana
dc.contributor.author Loo, Britt-Marie
dc.contributor.author Laaksonen, Reijo
dc.contributor.author Oksala, Niku
dc.contributor.author Kähönen, Mika
dc.contributor.author Hutri-Kähönen, Nina
dc.contributor.author Raitakari, Olli
dc.contributor.author Lehtimäki, Terho
dc.contributor.author Raitoharju, Emma
dc.date.accessioned 2020-02-19T08:21:01Z
dc.date.available 2020-02-19T08:21:01Z
dc.date.issued 2019-06-20
dc.identifier.citation Mononen , N , Lyytikäinen , L-P , Seppälä , I , Mishra , P P , Juonala , M , Waldenberger , M , Klopp , N , Illig , T , Leiviskä , J , Loo , B-M , Laaksonen , R , Oksala , N , Kähönen , M , Hutri-Kähönen , N , Raitakari , O , Lehtimäki , T & Raitoharju , E 2019 , ' Whole blood microRNA levels associate with glycemic status and correlate with target mRNAs in pathways important to type 2 diabetes ' , Scientific Reports , vol. 9 , 8887 . https://doi.org/10.1038/s41598-019-43793-4
dc.identifier.other PURE: 132316962
dc.identifier.other PURE UUID: 1c632807-1090-453a-a7e6-443dcb87ee42
dc.identifier.other WOS: 000472136900061
dc.identifier.uri http://hdl.handle.net/10138/311917
dc.description.abstract We analyzed the associations between whole blood microRNA profiles and the indices of glucose metabolism and impaired fasting glucose and examined whether the discovered microRNAs correlate with the expression of their mRNA targets. MicroRNA and gene expression profiling were performed for the Young Finns Study participants (n= 871). Glucose, insulin, and glycated hemoglobin (HbA1c) levels were measured, the insulin resistance index (HOMA2-IR) was calculated, and the glycemic status (normoglycemic [n = 534]/impaired fasting glucose [IFG] [n = 252]/type 2 diabetes [T2D] [n = 24]) determined. Levels of hsa-miR-144-5p, -122-5p, -148a-3p, -589-5p, and hsa-let-7a-5p associated with glycemic status. hsa-miR-144-5p and -148a-3p associated with glucose levels, while hsa-miR-144-5p, -122-5p, -184, and -339-3p associated with insulin levels and HOMA2-IR, and hsa-miR-148a-3p, -15b-3p, -93-3p, -146b-5p, -221-3p, -18a-3p, -642a-5p, and -181-2-3p associated with HbA1c levels. The targets of hsa-miR-146b-5p that correlated with its levels were enriched in inflammatory pathways, and the targets of hsa-miR-221-3p were enriched in insulin signaling and T2D pathways. These pathways showed indications of co-regulation by HbA1c-associated miRNAs. There were significant differences in the microRNA profiles associated with glucose, insulin, or HOMA-IR compared to those associated with HbA1c. The HbA1c-associated miRNAs also correlated with the expression of target mRNAs in pathways important to the development ofT2D. en
dc.format.extent 14
dc.language.iso eng
dc.relation.ispartof Scientific Reports
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject GLUCOSE
dc.subject MELLITUS
dc.subject PLASMA
dc.subject REGULATOR
dc.subject DISEASE
dc.subject 3111 Biomedicine
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Whole blood microRNA levels associate with glycemic status and correlate with target mRNAs in pathways important to type 2 diabetes en
dc.type Article
dc.contributor.organization HUSLAB
dc.contributor.organization Department of Diagnostics and Therapeutics
dc.contributor.organization University of Helsinki
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1038/s41598-019-43793-4
dc.relation.issn 2045-2322
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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