Performance of Finnish biobanks in nationwide pulmonary carcinoid tumour research

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http://hdl.handle.net/10138/311960

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Vesterinen , T , Salmenkivi , K , Mustonen , H , Kuopio , T , Lappi-Blanco , E , Paavonen , T , Vainio , P , Knuuttila , A , Carpén , O , Haglund , C & Arola , J 2020 , ' Performance of Finnish biobanks in nationwide pulmonary carcinoid tumour research ' , Virchows Archiv , vol. 476 , no. 2 , pp. 273-283 . https://doi.org/10.1007/s00428-019-02625-6

Title: Performance of Finnish biobanks in nationwide pulmonary carcinoid tumour research
Author: Vesterinen, Tiina; Salmenkivi, Kaisa; Mustonen, Harri; Kuopio, Teijo; Lappi-Blanco, Elisa; Paavonen, Timo; Vainio, Paula; Knuuttila, Aija; Carpén, Olli; Haglund, Caj; Arola, Johanna
Contributor: University of Helsinki, HUSLAB
University of Helsinki, HUSLAB
University of Helsinki, HUS Abdominal Center
University of Helsinki, Department of Medicine
University of Helsinki, HUSLAB
University of Helsinki, HUS Abdominal Center
University of Helsinki, HUSLAB
Date: 2020-02
Language: eng
Number of pages: 11
Belongs to series: Virchows Archiv
ISSN: 1432-2307
URI: http://hdl.handle.net/10138/311960
Abstract: Finnish hospital-integrated biobanks administer millions of formalin-fixed paraffin-embedded tissue samples collected within the clinical diagnostics. According to the Finnish Biobank Act, these samples can be coupled with patients’ clinical follow-up data and the data retrieved from national health registries. We collected a nationwide pulmonary carcinoid tumour series from Finnish biobanks to study prognostic factors as well as to explore how the number of tumours found in the Finnish biobanks corresponds to the number of tumours registered by the Finnish Cancer Registry (FCR). Finnish biobanks identified 88% of the tumours registered by the FCR and were able to deliver 63%. The main reasons for lacking samples were paucity of resected primary tumour tissue, incompatible primary diagnosis, and the absence of tissue blocks in the archives. The main bottleneck in the sample application process was retrieving patient data. Altogether, we received 224 tumour samples with appropriate patient data and identified six prognostic factors for shorter disease-specific survival: age over 56 years at the time of diagnosis, tumour size over 2.5 cm, atypical histology, Ki-67 proliferation index higher than 2.5%, hilar/mediastinal lymph node involvement at the time of diagnosis, and the presence of metastatic disease. In conclusion, the Finnish biobank infrastructure offers excellent opportunities for tissue-based research. However, to be able to develop the biobank operations further, involving more medical knowledge in the sample and data acquisition process is a necessity. Also, when working with tissue samples collected over decades, histological expertise is essential for re-evaluation and re-classification of the samples.
Subject: 3122 Cancers
Biobank
Rare cancer
Pulmonary carcinoid
Prognosis
NEUROENDOCRINE TUMORS
SURGICAL RESECTION
SURVIVAL
EXPERIENCE
OUTCOMES
QUALITY
BURDEN
INDEX
RARE
3111 Biomedicine
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