FinnTwin12 Cohort : An Updated Review

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Rose , R , Salvatore , J E , Aaltonen , S , Barr , P , Bogl , L H , Byers , H , Heikkilä , K , Korhonen , T , Latvala , A , Palviainen , T , Ranjit , A , Whipp , A , Pulkkinen , L , Dick , D & Kaprio , J 2019 , ' FinnTwin12 Cohort : An Updated Review ' , Twin Research and Human Genetics , vol. 22 , no. 5 , pp. 302-311 . https://doi.org/10.1017/thg.2019.83

Title: FinnTwin12 Cohort : An Updated Review
Author: Rose, Richard; Salvatore, Jessica E.; Aaltonen, Sari; Barr, Peter; Bogl, Leonie H.; Byers, Holly; Heikkilä, Kauko; Korhonen, Tellervo; Latvala, Antti; Palviainen, Teemu; Ranjit, Anu; Whipp, Alyce; Pulkkinen, Lea; Dick, Danielle; Kaprio, Jaakko
Contributor organization: Population Research Unit (PRU)
Institute for Molecular Medicine Finland
Genetic Epidemiology
Institute of Criminology and Legal Policy
Staff Services
University of Helsinki
Centre of Excellence in Complex Disease Genetics
Department of Public Health
Date: 2019-10
Language: eng
Number of pages: 10
Belongs to series: Twin Research and Human Genetics
ISSN: 1832-4274
DOI: https://doi.org/10.1017/thg.2019.83
URI: http://hdl.handle.net/10138/312167
Abstract: This review offers an update on research conducted with FinnTwin12 (FT12), the youngest of the three Finnish Twin Cohorts. FT12 was designed as a two-stage study. In the first stage, we conducted multiwave questionnaire research enrolling all eligible twins born in Finland during 1983–1987 along with their biological parents. In stage 2, we intensively studied a subset of these twins with in-school assessments at age 12 and semistructured poly-diagnostic interviews at age 14. At baseline, parents of intensively studied twins were administered the adult version of the interview. Laboratory studies with repeat interviews, neuropsychological tests, and collection of DNA were made of intensively studied twins during follow-up in early adulthood. The basic aim of the FT12 study design was to obtain information on individual, familial and school/neighborhood risks for substance use/abuse prior to the onset of regular tobacco and alcohol use and then track trajectories of use and abuse and their consequences into adulthood. But the longitudinal assessments were not narrowly limited to this basic aim, and with multiwave, multirater assessments from ages 11 to 12, the study has created a richly informative data set for analyses of gene–environment interactions of both candidate genes and genomewide measures with measured risk-relevant environments. Because 25 years have elapsed since the start of the study, we are planning a fifth-wave follow-up assessment.
Subject: 3142 Public health care science, environmental and occupational health
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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