Effect of headspace gas on nucleation of amorphous paracetamol

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Palomäki , E A K , Yliruusi , J K & Ehlers , H 2019 , ' Effect of headspace gas on nucleation of amorphous paracetamol ' , Journal of Drug Delivery Science and Technology , vol. 51 , pp. 127-138 . https://doi.org/10.1016/j.jddst.2019.02.019

Title: Effect of headspace gas on nucleation of amorphous paracetamol
Author: Palomäki, Emmi A. K.; Yliruusi, Jouko K.; Ehlers, Henrik
Contributor: University of Helsinki, Faculty of Pharmacy
University of Helsinki, Divisions of Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
Date: 2019-06
Language: eng
Number of pages: 12
Belongs to series: Journal of Drug Delivery Science and Technology
ISSN: 1773-2247
URI: http://hdl.handle.net/10138/312183
Abstract: In this paper, the effect of the gaseous environment on recrystallization of amorphous paracetamol was investigated. The experiments were conducted with a headspace gas consisting of dry air, dry carbon dioxide, dry nitrogen and humid air in four temperatures ranging from 5 degrees C below onset of T-g to 5 degrees C above onset of T-g. The recrystallization was monitored using Raman spectroscopy and subsequent multivariate analysis. In temperatures below onset of T-g, the presence of oxygen delayed the onset of recrystallization, with an increasing delay with lower temperature. When comparing samples exposed to dry headspace gases, the crystallization was fastest below onset of Tg when exposed to nitrogen. Being an inert gas, nitrogen did not seem to interfere with the molecules allowing them to freely find their inherent arrangement, whereas the presence of oxygen delayed the formation of stabile nuclei. Above onset of T-g, no differences in onset of crystallization was detected between dry gas atmospheres. Amorphous paracetamol crystallized to form II in all measurements and the samples did not reach full crystallinity within the duration of the experiments. The results show that the headspace gas has an effect on nucleation in the amorphous sample.
Subject: Amorphism
Crystallization
Nucleation
Raman spectroscopy
Sorption
Paracetamol
RAMAN-SPECTROSCOPY
SURFACE CRYSTALLIZATION
GLASS-TRANSITION
PHYSICAL STABILITY
INDOMETHACIN
DYNAMICS
MOBILITY
FORMS
STATE
WATER
317 Pharmacy
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