The Prevalence of HSV, HHV-6, HPV and Mycoplasma genitalium in Chlamydia trachomatis positive and Chlamydia trachomatis Negative Urogenital Samples among Young Women in Finland

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Korhonen , S , Hokynar , K , Eriksson , T , Natunen , K , Paavonen , J , Lehtinen , M & Puolakkainen , M 2019 , ' The Prevalence of HSV, HHV-6, HPV and Mycoplasma genitalium in Chlamydia trachomatis positive and Chlamydia trachomatis Negative Urogenital Samples among Young Women in Finland ' , Pathogens , vol. 8 , no. 4 , 276 . https://doi.org/10.3390/pathogens8040276

Titel: The Prevalence of HSV, HHV-6, HPV and Mycoplasma genitalium in Chlamydia trachomatis positive and Chlamydia trachomatis Negative Urogenital Samples among Young Women in Finland
Författare: Korhonen, Suvi; Hokynar, Kati; Eriksson, Tiina; Natunen, Kari; Paavonen, Jorma; Lehtinen, Matti; Puolakkainen, Mirja
Medarbetare: University of Helsinki, HUSLAB
University of Helsinki, Department of Virology
University of Helsinki, HUS Gynecology and Obstetrics
University of Helsinki, HUSLAB
Datum: 2019-12-01
Språk: eng
Sidantal: 9
Tillhör serie: Pathogens
ISSN: 2076-0817
Permanenta länken (URI): http://hdl.handle.net/10138/312213
Abstrakt: Chlamydia trachomatis, Mycoplasma genitalium, herpes simplex virus (HSV) and human papillomavirus (HPV) cause sexually transmitted infections. In addition, human herpesvirus 6 (HHV-6) may be a genital co-pathogen. The prevalence rates of HSV, HHV-6, HPV, M. genitalium, and the C. trachomatis ompA genotypes were investigated by PCR in urogenital samples of the C. trachomatis nucleic acid amplification test positive (n = 157) and age-, community- and time-matched negative (n = 157) women. The prevalence of HPV DNA was significantly higher among the C. trachomatis positives than the C. trachomatis negatives (66% vs. 25%, p <0.001). The prevalence of HSV (1.9% vs. 0%), HHV-6 (11% vs. 14%), and M. genitalium DNA (4.5% vs. 1.9%) was not significantly different between the C. trachomatis-positive and -negative women. Thirteen per cent of test-of-cure specimens tested positive for C. trachomatis. The prevalence of HSV, HHV-6, HPV, M. genitalium, and the C. trachomatis ompA genotypes did not significantly differ between those who cleared the C. trachomatis infection (n = 105) and those who did not (n = 16). The higher prevalence of HPV DNA among the C. trachomatis positives suggests greater sexual activity and increased risk for sexually transmitted pathogens.
Subject: chlamydial co-infection
sexually transmitted infection
3111 Biomedicine
3123 Gynaecology and paediatrics
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