Sex and Iron Modify Fibroblast Growth Factor 23 Concentration in 1-Year-Old Children

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Holmlund-Suila , E , Enlund-Cerullo , M , Valkama , S , Hauta-alus , H , Rosendahl , J , Helve , O , Hytinantti , T , Viljakainen , H , Andersson , S & Mäkitie , O 2017 , ' Sex and Iron Modify Fibroblast Growth Factor 23 Concentration in 1-Year-Old Children ' , Journal of Clinical Endocrinology and Metabolism , vol. 102 , no. 12 , pp. 4526-4533 . https://doi.org/10.1210/jc.2017-01211

Title: Sex and Iron Modify Fibroblast Growth Factor 23 Concentration in 1-Year-Old Children
Author: Holmlund-Suila, Elisa; Enlund-Cerullo, Maria; Valkama, Saara; Hauta-alus, Helena; Rosendahl, Jenni; Helve, Otto; Hytinantti, Timo; Viljakainen, Heli; Andersson, Sture; Mäkitie, Outi
Contributor organization: Children's Hospital
Clinicum
University of Helsinki
HUS Children and Adolescents
Lastentautien yksikkö
Date: 2017-12-01
Language: eng
Number of pages: 8
Belongs to series: Journal of Clinical Endocrinology and Metabolism
ISSN: 0021-972X
DOI: https://doi.org/10.1210/jc.2017-01211
URI: http://hdl.handle.net/10138/312230
Abstract: Context: Fibroblast growth factor 23 (FGF23) plays an important role in phosphate homeostasis, but its regulation is inadequately characterized. Objective: To examine FGF23 regulators, especially sex and iron status, in early childhood. Design: A cross-sectional study involving 1-year-old children. Setting and Participants: Healthy term infants with a birth weight appropriate for gestational age were recruited to an ongoing vitamin D trial at Katiloopisto Maternity Hospital, Helsinki, Finland. At 12-month follow-up visits, serum FGF23, 25-hydroxyvitamin D (25OHD), phosphate, ionized calcium, parathyroid hormone, and iron status were measured. All 721 children (51% girls) with complete data were included. Main Outcome Measures: Intact and C-terminal FGF23 concentrations and iron status at 1 year of age. Results: Intact FGF23 was greater in girls than in boys [median, 44.4 pg/mL; interquartile range (IQR), 36.8 to 51.9; median, 40.9 pg/mL; IQR, 34.5 to 49.0, respectively; P <0.001]. C-terminal FGF23 was similar in boys and girls (median, 2.8 pmol/L; IQR, 2.1 to 3.7; median, 2.9 pmol/L; IQR, 2.2 to 3.7, respectively; P = 0.393). The iron concentration was positively associated with intact FGF23 and was the strongest modifier of intact FGF23 (regression coefficient, 0.498; 95% confidence interval, 0.333 to 0.663; P <0.001) with ferritin, season, ionized calcium, 25OHD, and sex as other covariates. The association between iron and C-terminal FGF23 was inversely related (regression coefficient, -0.072; 95% confidence interval, -0.092 to -0.051; P <0.001). Conclusions: At 1 year of age, FGF23 status was different in girls and boys, with intact FGF23 concentrations higher in girls. Iron modified FGF23 concentrations, with intact FGF23 higher and C-terminal lower, in those with greater iron concentrations.
Subject: DOMINANT HYPOPHOSPHATEMIC RICKETS
PHOSPHATE HOMEOSTASIS
DEFICIENCY
FGF23
METABOLISM
FERRITIN
INFANCY
AXIS
3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Rights: cc_by_nc
Usage restriction: openAccess
Self-archived version: acceptedVersion


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