Sex and Iron Modify Fibroblast Growth Factor 23 Concentration in 1-Year-Old Children

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Holmlund-Suila , E , Enlund-Cerullo , M , Valkama , S , Hauta-alus , H , Rosendahl , J , Helve , O , Hytinantti , T , Viljakainen , H , Andersson , S & Mäkitie , O 2017 , ' Sex and Iron Modify Fibroblast Growth Factor 23 Concentration in 1-Year-Old Children ' , Journal of Clinical Endocrinology and Metabolism , vol. 102 , no. 12 , pp. 4526-4533 . https://doi.org/10.1210/jc.2017-01211

Title: Sex and Iron Modify Fibroblast Growth Factor 23 Concentration in 1-Year-Old Children
Author: Holmlund-Suila, Elisa; Enlund-Cerullo, Maria; Valkama, Saara; Hauta-alus, Helena; Rosendahl, Jenni; Helve, Otto; Hytinantti, Timo; Viljakainen, Heli; Andersson, Sture; Mäkitie, Outi
Contributor: University of Helsinki, Children's Hospital
University of Helsinki, HUS Children and Adolescents
University of Helsinki, Children's Hospital
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Children's Hospital
University of Helsinki, HUS Children and Adolescents
University of Helsinki, HUS Children and Adolescents
University of Helsinki, HUS Children and Adolescents
Date: 2017-12-01
Language: eng
Number of pages: 8
Belongs to series: Journal of Clinical Endocrinology and Metabolism
ISSN: 0021-972X
URI: http://hdl.handle.net/10138/312230
Abstract: Context: Fibroblast growth factor 23 (FGF23) plays an important role in phosphate homeostasis, but its regulation is inadequately characterized. Objective: To examine FGF23 regulators, especially sex and iron status, in early childhood. Design: A cross-sectional study involving 1-year-old children. Setting and Participants: Healthy term infants with a birth weight appropriate for gestational age were recruited to an ongoing vitamin D trial at Katiloopisto Maternity Hospital, Helsinki, Finland. At 12-month follow-up visits, serum FGF23, 25-hydroxyvitamin D (25OHD), phosphate, ionized calcium, parathyroid hormone, and iron status were measured. All 721 children (51% girls) with complete data were included. Main Outcome Measures: Intact and C-terminal FGF23 concentrations and iron status at 1 year of age. Results: Intact FGF23 was greater in girls than in boys [median, 44.4 pg/mL; interquartile range (IQR), 36.8 to 51.9; median, 40.9 pg/mL; IQR, 34.5 to 49.0, respectively; P <0.001]. C-terminal FGF23 was similar in boys and girls (median, 2.8 pmol/L; IQR, 2.1 to 3.7; median, 2.9 pmol/L; IQR, 2.2 to 3.7, respectively; P = 0.393). The iron concentration was positively associated with intact FGF23 and was the strongest modifier of intact FGF23 (regression coefficient, 0.498; 95% confidence interval, 0.333 to 0.663; P <0.001) with ferritin, season, ionized calcium, 25OHD, and sex as other covariates. The association between iron and C-terminal FGF23 was inversely related (regression coefficient, -0.072; 95% confidence interval, -0.092 to -0.051; P <0.001). Conclusions: At 1 year of age, FGF23 status was different in girls and boys, with intact FGF23 concentrations higher in girls. Iron modified FGF23 concentrations, with intact FGF23 higher and C-terminal lower, in those with greater iron concentrations.
Subject: DOMINANT HYPOPHOSPHATEMIC RICKETS
PHOSPHATE HOMEOSTASIS
DEFICIENCY
FGF23
METABOLISM
FERRITIN
INFANCY
AXIS
3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
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