Developments and opportunities in fungal strain engineering for the production of novel enzymes and enzyme cocktails for plant biomass degradation

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http://hdl.handle.net/10138/312372

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Kun , R , Gomes , A C S , Hilden , S K , Salazar Cerezo , S , Mäkelä , M R & de Vries , R 2019 , ' Developments and opportunities in fungal strain engineering for the production of novel enzymes and enzyme cocktails for plant biomass degradation ' , Biotechnology Advances , vol. 37 , no. 6 , 107361 . https://doi.org/10.1016/j.biotechadv.2019.02.017

Title: Developments and opportunities in fungal strain engineering for the production of novel enzymes and enzyme cocktails for plant biomass degradation
Author: Kun, Roland; Gomes, Ana Carolina S.; Hilden, Sari Kristiina; Salazar Cerezo, Sonia; Mäkelä, Miia Riitta; de Vries, Ronald
Contributor: University of Helsinki, Department of Microbiology
University of Helsinki, Helsinki Institute of Sustainability Science (HELSUS)
Date: 2019-11-01
Language: eng
Number of pages: 16
Belongs to series: Biotechnology Advances
ISSN: 0734-9750
URI: http://hdl.handle.net/10138/312372
Abstract: Fungal strain engineering is commonly used in many areas of biotechnology, including the production of plant biomass degrading enzymes. Its aim varies from the production of specific enzymes to overall increased enzyme production levels and modification of the composition of the enzyme set that is produced by the fungus. Strain engineering involves a diverse range of methodologies, including classical mutagenesis, genetic engineering and genome editing. In this review, the main approaches for strain engineering of filamentous fungi in the field of plant biomass degradation will be discussed, including recent and not yet implemented methods, such as CRISPR/Cas9 genome editing and adaptive evolution.
Subject: 1182 Biochemistry, cell and molecular biology
UV mutagenesis
Chemical mutagenesis
Adaptive evolution
Genetic engineering
Genome editing
Epigenetics
Omits
SOLID-STATE FERMENTATION
POLYSACCHARIDE-DEGRADING ENZYMES
MANNAN UTILIZATION SYSTEM
TRICHODERMA-REESEI
ASPERGILLUS-NIGER
SACCHAROMYCES-CEREVISIAE
CELLULASE PRODUCTION
TRANSCRIPTIONAL ACTIVATOR
HYPER-PRODUCTION
GENE-EXPRESSION
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