Genetic variation in GC and CYP2R1 affects 25-hydroxyvitamin D concentration and skeletal parameters: A genome-wide association study in 24-month-old Finnish children

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dc.contributor University of Helsinki, University of Helsinki en
dc.contributor University of Helsinki, Lastentautien yksikkö en
dc.contributor University of Helsinki, Clinicum en
dc.contributor University of Helsinki, HUS Children and Adolescents en
dc.contributor University of Helsinki, HUS Children and Adolescents en
dc.contributor University of Helsinki, HUS Children and Adolescents en
dc.contributor University of Helsinki, Clinicum en
dc.contributor University of Helsinki, HUS Children and Adolescents en
dc.contributor.author Kämpe, Anders
dc.contributor.author Enlund-Cerullo, Maria
dc.contributor.author Valkama, Saara
dc.contributor.author Holmlund-Suila, Elisa
dc.contributor.author Rosendahl, Jenni
dc.contributor.author Hauta-alus, Helena
dc.contributor.author Pekkinen, Minna
dc.contributor.author Andersson, Sture
dc.contributor.author Mäkitie, Outi
dc.date.accessioned 2020-02-27T10:51:02Z
dc.date.available 2020-02-27T10:51:02Z
dc.date.issued 2019-12-16
dc.identifier.citation Kämpe , A , Enlund-Cerullo , M , Valkama , S , Holmlund-Suila , E , Rosendahl , J , Hauta-alus , H , Pekkinen , M , Andersson , S & Mäkitie , O 2019 , ' Genetic variation in GC and CYP2R1 affects 25-hydroxyvitamin D concentration and skeletal parameters: A genome-wide association study in 24-month-old Finnish children ' , PLoS Genetics , vol. 15 , no. 12 , e1008530 . https://doi.org/10.1371/journal.pgen.1008530 en
dc.identifier.issn 1553-7390
dc.identifier.other PURE: 131100900
dc.identifier.other PURE UUID: 7c5e1439-b32c-48bb-8c9b-7e06b1edcaab
dc.identifier.other RIS: urn:931B88371C117AA9663A43697C84B780
dc.identifier.other WOS: 000512336600031
dc.identifier.uri http://hdl.handle.net/10138/312393
dc.description.abstract Author summary The effect of vitamin D continues to be highly debated in various health outcomes, including bone health. In this first study of children this young we searched for genes that modify vitamin D metabolism in early childhood using a genome-wide analysis of almost 700,000 genetic variants in a cohort of 761 healthy children participating in a vitamin D intervention study. We show that genetic variation in the genes coding for Vitamin D binding protein (GC) and Vitamin D 25-hydroxylase (CYP2R1) are important determinants for serum 25-hydroxyvitamin D concentration in 2-year-old children. Genetic variants within the GC gene also affect how the child responds to vitamin D supplementation. Moreover, our findings suggest that in 2-year-old children vitamin D concentration, even when within the normal range, influences bone strength as children with genetic constellations associating with lower vitamin D concentration and poorer response to vitamin D supplementation also have weaker bones. en
dc.language.iso eng
dc.relation.ispartof PLoS Genetics
dc.rights en
dc.subject 3123 Gynaecology and paediatrics en
dc.subject 1184 Genetics, developmental biology, physiology en
dc.title Genetic variation in GC and CYP2R1 affects 25-hydroxyvitamin D concentration and skeletal parameters: A genome-wide association study in 24-month-old Finnish children en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.1371/journal.pgen.1008530
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion
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