Point-of-care laboratory analyses of intraosseous, arterial and central venous samples during experimental cardiopulmonary resuscitation

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dc.contributor.author Jousi, Mille
dc.contributor.author Skrifvars, Markus B.
dc.contributor.author Nelskylä, Annika
dc.contributor.author Ristagno, Giuseppe
dc.contributor.author Schramko, Alexey
dc.contributor.author Nurmi, Jouni
dc.date.accessioned 2020-02-28T01:43:56Z
dc.date.available 2021-12-17T22:45:19Z
dc.date.issued 2019-04
dc.identifier.citation Jousi , M , Skrifvars , M B , Nelskylä , A , Ristagno , G , Schramko , A & Nurmi , J 2019 , ' Point-of-care laboratory analyses of intraosseous, arterial and central venous samples during experimental cardiopulmonary resuscitation ' , Resuscitation , vol. 137 , pp. 124-132 . https://doi.org/10.1016/j.resuscitation.2019.02.014
dc.identifier.other PURE: 123847172
dc.identifier.other PURE UUID: 3730bc21-f9ea-4e5a-bc44-e2a6cd8c535e
dc.identifier.other WOS: 000461593400017
dc.identifier.other Scopus: 85062150760
dc.identifier.uri http://hdl.handle.net/10138/312429
dc.description.abstract Introduction: Screening and correcting reversible causes of cardiac arrest (CA) are an essential part of cardiopulmonary resuscitation (CPR). Point-ofcare (POC) laboratory analyses are used for screening pre-arrest pathologies, such as electrolyte disorders and acid-base balance disturbances. The aims of this study were to compare the intraosseous (10), arterial and central venous POC values during CA and CPR and to see how the CPR values reflect the pre-arrest state. Methods: We performed an experimental study on 23 anaesthetised pigs. After induction of ventricular fibrillation (VF), we obtained POC samples from the 10 space, artery and central vein simultaneously at three consecutive time points. We observed the development of the values during CA and CPR and compared the CPR values to the pre-arrest values. Results: The 10, arterial and venous values changed differently from one another during the course of CA and CPR. Base excess and pH decreased in the venous and 10 samples during untreated VF, but in the arterial samples, this only occurred after the onset of CPR. The 10, arterial and venous potassium values were higher during CPR compared to the pre-arrest arterial values (mean elevations 4.4 mmol/l (SD 0.72), 3.3 mmol/l (0.78) and 2.8 mmol/l (0.94), respectively). Conclusions: A dynamic change occurs in the common laboratory values during CA and CPR. POC analyses of lactate, pH, sodium and calcium within 10 samples are not different from analyses of arterial or venous blood. Potassium values in 10, arterial and venous samples during CPR are higher than the pre-arrest arterial values. en
dc.format.extent 9
dc.language.iso eng
dc.relation.ispartof Resuscitation
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Intra-osseous access
dc.subject Cardiopulmonary resuscitation
dc.subject Resuscitation
dc.subject Point-of-care
dc.subject Laboratory analysis
dc.subject Blood gas analysis
dc.subject Emergency medicine
dc.subject ACID-BASE STATUS
dc.subject CARDIAC-ARREST
dc.subject BLOOD-GASES
dc.subject COUNCIL GUIDELINES
dc.subject VASCULAR ACCESS
dc.subject SITES
dc.subject 3126 Surgery, anesthesiology, intensive care, radiology
dc.title Point-of-care laboratory analyses of intraosseous, arterial and central venous samples during experimental cardiopulmonary resuscitation en
dc.type Article
dc.contributor.organization HUS Emergency Medicine and Services
dc.contributor.organization Anestesiologian yksikkö
dc.contributor.organization Department of Diagnostics and Therapeutics
dc.contributor.organization Clinicum
dc.contributor.organization University of Helsinki
dc.contributor.organization HUS Perioperative, Intensive Care and Pain Medicine
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.resuscitation.2019.02.014
dc.relation.issn 0300-9572
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion
dc.type.version publishedVersion

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