Epstein-Barr virus and human papillomaviruses as favorable prognostic factors in nasopharyngeal carcinoma : A nationwide study in Finland

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Ruuskanen , M , Irjala , H , Minn , H , Vahlberg , T , Randen-Brady , R , Hagström , J , Syrjänen , S & Leivo , I 2019 , ' Epstein-Barr virus and human papillomaviruses as favorable prognostic factors in nasopharyngeal carcinoma : A nationwide study in Finland ' , Head & Neck , vol. 41 , no. 2 , pp. 349-357 . https://doi.org/10.1002/hed.25450

Title: Epstein-Barr virus and human papillomaviruses as favorable prognostic factors in nasopharyngeal carcinoma : A nationwide study in Finland
Author: Ruuskanen, Miia; Irjala, Heikki; Minn, Heikki; Vahlberg, Tero; Randen-Brady, Reija; Hagström, Jaana; Syrjänen, Stina; Leivo, Ilmo
Contributor: University of Helsinki, Department of Pathology
University of Helsinki, Medicum
Date: 2019-02
Language: eng
Number of pages: 9
Belongs to series: Head & Neck
ISSN: 1043-3074
URI: http://hdl.handle.net/10138/312541
Abstract: Background Nasopharyngeal carcinoma (NPC) is related to Epstein-Barr virus (EBV) in endemic areas; however, the role of viruses in nonendemic countries is unclear. Our nationwide study investigated the prevalence and prognostic significance of EBV and human papillomaviruses (HPVs) in Finnish NPC tumors. Methods We analyzed samples from 150 patients diagnosed between 1990 and 2009. Viral status was determined using EBV and HPV RNA in situ hybridizations, and p16 immunohistochemistry. Patient and treatment characteristics were obtained from patient records. Results In our white patient cohort, 93 of 150 (62%) patients were EBV-positive and 21/150 (14%) patients were HPV-positive with no coinfections. Thirty-six (24%) tumors were negative for both viruses. The 5-year disease-specific survival for patients with EBV-positive, HPV-positive, and EBV/HPV-negative tumors was 69%, 63%, and 39%, respectively. In multivariable-adjusted analysis, overall survival was better among patients with EBV-positive (P = .005) and HPV-positive (P = .03) tumors compared to patients with EBV/HPV-negative tumors. Conclusions In our low-incidence population, EBV and HPV are important prognostic factors for NPC.
Subject: Epstein-Barr virus
human papillomavirus
nasopharyngeal carcinoma
p16 immunohistochemistry
viral carcinogenesis
ANTITUMOR-ACTIVITY
CANCER
HEAD
HPV
EBV
INFECTION
SURVIVAL
EASTERN
DNA
3125 Otorhinolaryngology, ophthalmology
3126 Surgery, anesthesiology, intensive care, radiology
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