Anthropometric and reproductive factors and risk of esophageal and gastric cancer by subtype and subsite: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

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Sanikini , H , Muller , D C , Sophiea , M , Rinaldi , S , Agudo , A , Duell , E J , Weiderpass , E , Overvad , K , Tjønneland , A , Halkjær , J , Boutron-Ruault , M-C , Carbonnel , F , Cervenka , I , Boeing , H , Kaaks , R , Kühn , T , Trichopoulou , A , Martimianaki , G , Karakatsani , A , Pala , V , Palli , D , Mattiello , A , Tumino , R , Sacerdote , C , Skeie , G , Rylander , C , López , M D C , Sánchez , M-J , Ardanaz , E , Regnér , S , Stocks , T , Bueno-de-Mesquita , B , Vermeulen , R C H , Aune , D , Tong , T Y N , Kliemann , N , Murphy , N , Chadeau-Hyam , M , Gunter , M J & Cross , A J 2019 , ' Anthropometric and reproductive factors and risk of esophageal and gastric cancer by subtype and subsite: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort ' , International Journal of Cancer , vol. 146 , no. 4 , pp. 929-942 . https://doi.org/10.1002/ijc.32386

Title: Anthropometric and reproductive factors and risk of esophageal and gastric cancer by subtype and subsite: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
Author: Sanikini, Harinakshi; Muller, David C; Sophiea, Marisa; Rinaldi, Sabina; Agudo, Antonio; Duell, Eric J; Weiderpass, Elisabete; Overvad, Kim; Tjønneland, Anne; Halkjær, Jytte; Boutron-Ruault, Marie-Christine; Carbonnel, Franck; Cervenka, Iris; Boeing, Heiner; Kaaks, Rudolf; Kühn, Tilman; Trichopoulou, Antonia; Martimianaki, Georgia; Karakatsani, Anna; Pala, Valeria; Palli, Domenico; Mattiello, Amalia; Tumino, Rosario; Sacerdote, Carlotta; Skeie, Guri; Rylander, Charlotta; López, María Dolores Chirlaque; Sánchez, Maria-Jose; Ardanaz, Eva; Regnér, Sara; Stocks, Tanja; Bueno-de-Mesquita, Bas; Vermeulen, Roel C.H.; Aune, Dagfinn; Tong, Tammy Y.N.; Kliemann, Nathalie; Murphy, Neil; Chadeau-Hyam, Marc; Gunter, Marc J; Cross, Amanda J
Contributor: University of Helsinki, Department of Medical and Clinical Genetics
Date: 2019-02-15
Language: eng
Number of pages: 14
Belongs to series: International Journal of Cancer
ISSN: 0020-7136
URI: http://hdl.handle.net/10138/312584
Abstract: Obesity has been associated with upper gastrointestinal cancers; however, there are limited prospective data on associations by subtype/subsite. Obesity can impact hormonal factors, which have been hypothesized to play a role in these cancers. We investigated anthropometric and reproductive factors in relation to esophageal and gastric cancer by subtype and subsite for 476,160 participants from the European Prospective Investigation into Cancer and Nutrition cohort. Multivariable hazard ratios (HRs) and 95%-confidence intervals (CIs) were estimated using Cox models. During a mean follow-up of 14 years, 220 esophageal adenocarcinomas (EA), 195 esophageal squamous cell carcinomas, 243 gastric cardia (GC) and 373 gastric non-cardia (GNC) cancers were diagnosed. Body mass index (BMI) was associated with EA in men (BMI≥30 vs 18.5-25kg/m2: HR=1.94, 95%-CI: 1.25-3.03) and women (HR=2.66, 95%-CI: 1.15-6.19); however, adjustment for waist-to-hip ratio (WHR) attenuated these associations. WHR and waist circumference (WC) were associated with EA in men (HR=3.47, 95%-CI: 1.99-6.06 for WHR >0.96 vs 98 vs 0.82 vs 83 vs 2 vs 0) and age at first pregnancy and GNC (HR=0.54, 95%-CI: 0.32-0.91; >26 vs
Subject: Obesity
reproductive
hormones
esophageal
gastric
cancer
3122 Cancers
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