Clinical Study of Nanofibrillar Cellulose Hydrogel Dressing for Skin Graft Donor Site Treatment

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http://hdl.handle.net/10138/312613

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Koivuniemi , R , Hakkarainen , T , Kiiskinen , J , Kosonen , M , Vuola , J , Valtonen , J , Luukko , K , Kavola , H & Yliperttula , M 2020 , ' Clinical Study of Nanofibrillar Cellulose Hydrogel Dressing for Skin Graft Donor Site Treatment ' , Advances in wound care , vol. 9 , no. 4 , pp. 199-210 . https://doi.org/10.1089/wound.2019.0982

Title: Clinical Study of Nanofibrillar Cellulose Hydrogel Dressing for Skin Graft Donor Site Treatment
Author: Koivuniemi, Raili; Hakkarainen, Tiina; Kiiskinen, Jasmi; Kosonen, Mika; Vuola, Jyrki; Valtonen, Jussi; Luukko, Kari; Kavola, Heli; Yliperttula, Marjo
Contributor: University of Helsinki, Division of Pharmaceutical Biosciences
University of Helsinki, Division of Pharmaceutical Biosciences
University of Helsinki, Division of Pharmaceutical Biosciences
University of Helsinki, University of Helsinki
University of Helsinki, HUS Musculoskeletal and Plastic Surgery
University of Helsinki, HUS Musculoskeletal and Plastic Surgery
University of Helsinki, Division of Pharmaceutical Biosciences
Date: 2020-02-07
Language: eng
Number of pages: 12
Belongs to series: Advances in wound care
ISSN: 2162-1918
URI: http://hdl.handle.net/10138/312613
Abstract: Objective: Skin graft donor site management is a concern particularly for elderly patients and patients with poor wound healing competence, and also because donor sites are a source of pain and discomfort. Although different types of dressings exist, there is no consensus regarding optimal dressing type on donor site care to promote healing, reduce pain, and improve patients' comfort. Approach: This prospective, single-center clinical trial evaluated the performance of nanofibrillar cellulose (NFC) wound dressing (FibDex (R) by UPM-Kymmene Corporation) for treatment of donor sites compared with a polylactide-based copolymer dressing. The study enrolled 24 patients requiring skin grafting with mean age of 49 +/- 18. The primary outcome measure was wound healing time. Secondary outcomes, the epithelialization, subjective pain, the scar appearance assessed using the Patient and Observer Scar Assessment Scale (POSAS), and skin elasticity and transepidermal water loss (TEWL), were evaluated at 1 and 6 months postoperatively. Results: No statistically significant differences were observed between NFC and copolymer dressings regarding wound healing time, epithelialization, experience of pain, or TEWL. Significant differences were observed in the POSAS results for thickness and vascularity in the Observer score, in the favor of NFC over copolymer dressing. Moreover, skin elasticity was significantly improved with NFC dressing in terms of viscoelasticity and elastic modulus at 1 month postoperatively. Innovation: NFC dressing is a new, green sustainable product for wound treatment without animal or human-origin components. Conclusion: NFC dressing provides efficient wound healing at skin graft donor sites and is comparable or even preferable compared with the copolymer dressing.
Subject: nanofibrillar cellulose
wound dressing
skin graft donor site treatment
patient
clinical study
BACTERIAL CELLULOSE
MICROBIAL CELLULOSE
IN-VIVO
NANOCELLULOSE
MANAGEMENT
SUBSTITUTE
COLLAGEN
RELEASE
PATIENT
CELL
3111 Biomedicine
317 Pharmacy
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