Schizophrenia and pregnancy: a national register-based follow-up study among Finnish women born between 1965 and 1980

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Simoila , L , Isometsä , E , Gissler , M , Suvisaari , J , Halmesmäki , E & Lindberg , N 2020 , ' Schizophrenia and pregnancy: a national register-based follow-up study among Finnish women born between 1965 and 1980 ' , Archives of Women's Mental Health , vol. 23 , no. 1 , pp. 91-100 . https://doi.org/10.1007/s00737-019-0948-0

Title: Schizophrenia and pregnancy: a national register-based follow-up study among Finnish women born between 1965 and 1980
Author: Simoila, Laura; Isometsä, Erkki; Gissler, Mika; Suvisaari, Jaana; Halmesmäki, Erja; Lindberg, Nina
Contributor: University of Helsinki, Department of Psychiatry
University of Helsinki, Department of Psychiatry
University of Helsinki, National Institute for Health and Welfare (THL)
University of Helsinki, HUS Gynecology and Obstetrics
University of Helsinki, Department of Psychiatry
Date: 2020-02
Language: eng
Number of pages: 10
Belongs to series: Archives of Women's Mental Health
ISSN: 1435-1102
URI: http://hdl.handle.net/10138/312681
Abstract: To assess psychosocial and somatic risk factors related to pregnancy, and pregnancy-related complications or disorders in women with schizophrenia compared to population controls. In this register-based cohort study, we identified all Finnish women who were born in 1965–1980 and diagnosed with schizophrenia in psychiatric care before 31 December 2013. For each case, five age- and place-of-birth matched controls were randomly selected. They were followed from the day when the disorder was diagnosed in specialized health care till the end of 2013. The mean follow-up time was 14.0 + 6.91 vs. 14.3 + 6.89 years. Altogether, 1162 singleton pregnancies were found among affected women and 4683 among controls. Affected women were significantly older and more often single; their body mass index before pregnancy was significantly higher, and they smoked significantly more often both in the beginning of pregnancy and after the first trimester than controls. They showed a significantly higher odds for pathologic oral glucose tolerance test (odds ratio (OR) 1.66, 95% confidence interval (95% CI) 1.27–2.17), initiation of insulin treatment (OR 1.84, 95% CI 1.15–2.93), fast fetal growth (OR 1.62, 95% CI 1.03–2.52), premature contractions (OR 2.42, 95% CI 1.31–4.49), hypertension (OR 1.81, 95% CI 1.01–3.27), and pregnancy-related hospitalizations (OR 1.97, 95% CI 1.66–2.33). Suspected damage to the fetus from alcohol/drugs was significantly more common among affected women than controls. Women with schizophrenia have higher prevalence of psychosocial and somatic risk factors related to pregnancy, as well as pregnancy-related complications and disorders than non-affected women.
Subject: 3124 Neurology and psychiatry
Pregnancy
Conditions related to or aggravated by the pregnancy
Schizoaffective disorder
SCHIZOPHRENIA
WOMEN
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