Long-term quality of life after surgery of head and neck cancer with microvascular reconstruction : a prospective study with 4.9-years follow-up

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Kainulainen , S , Koivusalo , A M , Roine , R P , Wilkman , T , Sintonen , H , Törnwall , J , Thoren , H & Lassus , P 2020 , ' Long-term quality of life after surgery of head and neck cancer with microvascular reconstruction : a prospective study with 4.9-years follow-up ' , Oral and Maxillofacial Surgery , vol. 24 , no. 1 , pp. 11-17 . https://doi.org/10.1007/s10006-019-00806-w

Title: Long-term quality of life after surgery of head and neck cancer with microvascular reconstruction : a prospective study with 4.9-years follow-up
Author: Kainulainen, Satu; Koivusalo, A. M.; Roine, R. P.; Wilkman, T.; Sintonen, H.; Törnwall, J.; Thoren, H.; Lassus, P.
Contributor: University of Helsinki, Department of Oral and Maxillofacial Diseases
University of Helsinki, HUS Perioperative, Intensive Care and Pain Medicine
University of Helsinki, HUS Helsinki and Uusimaa Hospital District
University of Helsinki, HUS Head and Neck Center
University of Helsinki, Clinicum
University of Helsinki, University of Helsinki
University of Helsinki, University of Turku
University of Helsinki, HUS Musculoskeletal and Plastic Surgery
Date: 2020-03
Language: eng
Number of pages: 7
Belongs to series: Oral and Maxillofacial Surgery
ISSN: 1865-1550
URI: http://hdl.handle.net/10138/312688
Abstract: Purpose The aim of this study was to evaluate the long-term health-related quality of life (HRQoL) of head and neck cancer patients with microvascular surgery. Surgical treatment causes great changes in patient HRQoL. Studies focusing on long-term HRQoL after microvascular reconstruction for head and neck cancer patients are scarce. Methods We conducted a prospective study of 93 patients with head and neck cancer and microvascular reconstruction in Helsinki University Hospital Finland. HRQoL was measured using the 15D instrument at baseline and after a mean 4.9-years follow up. Results were compared with those of an age-standardized general population. Results Of the 93 patients, 61 (66%) were alive after follow-up; of these, 42 (69%) answered the follow-up questionnaire. The median time between surgery and HRQoL assessment was 4.9 years (range 3.7-7.8 years). The mean 15D score of all patients (n = 42) at the 4.9-years follow up was statistically significantly (p = 0.010) and clinically importantly lower than at baseline. The dimensions of "speech" and "usual activities" were significantly impaired at the end of follow up. There was a significant difference at the 4.9-years follow-up in the mean 15D score between patients and the general population (p = 0.014). After follow up, patients were significantly (p <0.05) worse off on the dimensions of "speech," "eating," and "usual activities." Conclusions Long-term HRQoL was significantly reduced in the whole patient cohort. Speech and usual activities were the most affected dimensions in head and neck cancer patients with microvascular reconstruction at the end of the 4.9-years follow up.
Subject: Head and neck cancer
Health-related quality of life
Microvascular reconstruction
Surgery
SURVIVORS
VALIDITY
OUTCOMES
313 Dentistry
3126 Surgery, anesthesiology, intensive care, radiology
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