Anaerobic Degradation of N-epsilon-Carboxymethyllysine, a Major Glycation End-Product, by Human Intestinal Bacteria

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Bui , T P N , Troise , A D , Fogliano , V & de Vos , W M 2019 , ' Anaerobic Degradation of N-epsilon-Carboxymethyllysine, a Major Glycation End-Product, by Human Intestinal Bacteria ' , Journal of Agricultural and Food Chemistry , vol. 67 , no. 23 , pp. 6594-6602 . https://doi.org/10.1021/acs.jafc.9b02208

Title: Anaerobic Degradation of N-epsilon-Carboxymethyllysine, a Major Glycation End-Product, by Human Intestinal Bacteria
Author: Bui, Thi Phuong Nam; Troise, Antonio Dario; Fogliano, Vincenzo; de Vos, Willem M.
Contributor: University of Helsinki, Medicum
Date: 2019-06-12
Language: eng
Number of pages: 9
Belongs to series: Journal of Agricultural and Food Chemistry
ISSN: 0021-8561
URI: http://hdl.handle.net/10138/312695
Abstract: Modifications of lysine contribute to the amount of dietary advanced glycation end-products reaching the colon. However, little is known about the ability of intestinal bacteria to metabolize dietary N-epsilon-carboxymethyllysine (CML). Successive transfers of fecal microbiota in growth media containing CML were used to identify and isolate species able to metabolize CML under anaerobic conditions. From our study, only donors exposed to processed foods degraded CML, and anaerobic bacteria enrichments from two of them used 77 and 100% of CML. Oscillibacter and Cloacibacillus evryensis increased in the two donors after the second transfer, highlighting that the bacteria from these taxa could be candidates for anaerobic CML degradation. A tentative identification of CML metabolites produced by a pure culture of Cloacibacillus evryensis was performed by mass spectrometry: carboxymethylated biogenic amines and carboxylic acids were identified as CML degradation products. The study confirmed the ability of intestinal bacteria to metabolize CML under anoxic conditions.
Subject: CML
CONSEQUENCES
FOOD
FUROSINE
GUT MICROBIOTA
MAILLARD REACTION-PRODUCTS
METABOLISM
Maillard reaction
N-epsilon-carboxymethyllysine
STRAINS
dietary advanced glycation end-products
intestinal metabolism
microbiota
116 Chemical sciences
3143 Nutrition
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