Coupling between dynamic 3D tissue architecture and BMP morphogen signaling during Drosophila wing morphogenesis

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http://hdl.handle.net/10138/312763

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Gui , J , Huang , Y , Kracklauer , M , Toddie-Moore , D J , Kikushima , K , Nix , S , Ishimoto , Y & Shimmi , O 2019 , ' Coupling between dynamic 3D tissue architecture and BMP morphogen signaling during Drosophila wing morphogenesis ' , Proceedings of the National Academy of Sciences of the United States of America , vol. 116 , no. 10 , pp. 4352-4361 . https://doi.org/10.1073/pnas.1815427116

Title: Coupling between dynamic 3D tissue architecture and BMP morphogen signaling during Drosophila wing morphogenesis
Author: Gui, Jinghua; Huang, Yunxian; Kracklauer, Martin; Toddie-Moore, Daniel John; Kikushima, Kenji; Nix, Stephanie; Ishimoto, Yukitaka; Shimmi, Osamu
Other contributor: University of Helsinki, Institute of Biotechnology
University of Helsinki, Institute of Biotechnology
University of Helsinki, Morphogenesis and cellular dynamics
University of Helsinki, Institute of Biotechnology
University of Helsinki, Morphogenesis and cellular dynamics
University of Helsinki, Morphogenesis and cellular dynamics

Date: 2019-03-05
Language: eng
Number of pages: 10
Belongs to series: Proceedings of the National Academy of Sciences of the United States of America
ISSN: 0027-8424
DOI: https://doi.org/10.1073/pnas.1815427116
URI: http://hdl.handle.net/10138/312763
Abstract: At the level of organ formation, tissue morphogenesis drives developmental processes in animals, often involving the rearrangement of two-dimensional (2D) structures into more complex three-dimensional (3D) tissues. These processes can be directed by growth factor signaling pathways. However, little is known about how such morphological changes affect the spatiotemporal distribution of growth factor signaling. Here, using the Drosophila pupal wing, we address how decapentaplegic (Dpp)/bone morphogenetic protein (BMP) signaling and 3D wing morphogenesis are coordinated. Dpp, expressed in the longitudinal veins (LVs) of the pupal wing, initially diffuses laterally within both dorsal and ventral wing epithelia during the inflation stage to regulate cell proliferation. Dpp localization is then refined to the LVs within each epithelial plane, but with active interplanar signaling for vein patterning/differentiation, as the two epithelia appose. Our data further suggest that the 3D architecture of the wing epithelia and the spatial distribution of BMP signaling are tightly coupled, revealing that 3D morphogenesis is an emergent property of the interactions between extracellular signaling and tissue shape changes.
Subject: BRINKER
CLEFT-PALATE
DECAPENTAPLEGIC GENE
DPP
GRADIENT
GROWTH
MECHANISMS
ORGANIZATION
PATTERNS
PROLIFERATION
bone orphogenetic protein
drosophila
epithelial morphogenesis
live-imaging
three-dimensional architecture
1184 Genetics, developmental biology, physiology
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