Establishing a hepatitis C continuum of care among HIV/hepatitis C virus-coinfected individuals in EuroSIDA

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EuroSIDA Study Grp , Amele , S , Ristola , M , Mocroft , A & Aho , I 2019 , ' Establishing a hepatitis C continuum of care among HIV/hepatitis C virus-coinfected individuals in EuroSIDA ' , HIV Medicine , vol. 20 , no. 4 , pp. 264-273 . https://doi.org/10.1111/hiv.12711

Title: Establishing a hepatitis C continuum of care among HIV/hepatitis C virus-coinfected individuals in EuroSIDA
Author: EuroSIDA Study Grp; Amele, S.; Ristola, M.; Mocroft, A.; Aho, I.
Contributor: University of Helsinki, Clinicum
University of Helsinki, Infektiosairauksien yksikkö
Date: 2019-04
Language: eng
Number of pages: 10
Belongs to series: HIV Medicine
ISSN: 1464-2662
URI: http://hdl.handle.net/10138/312871
Abstract: Objectives The aim of the study was to establish a methodology for evaluating the hepatitis C continuum of care in HIV/hepatitis C virus (HCV)-coinfected individuals and to characterize the continuum in Europe on 1 January 2015, prior to widespread access to direct-acting antiviral (DAA) therapy. Methods Stages included in the continuum were as follows: anti-HCV antibody positive, HCV RNA tested, currently HCV RNA positive, ever HCV RNA positive, ever received HCV treatment, completed HCV treatment, follow-up HCV RNA test, and cure. Sustained virological response (SVR) could only be assessed for those with a follow-up HCV RNA test and was defined as a negative HCV RNA result measured > 12 or 24 weeks after stopping treatment. Results Numbers and percentages for the stages of the HCV continuum of care were as follows: anti-HCV positive (n = 5173), HCV RNA tested (4207 of 5173; 81.3%), currently HCV RNA positive (3179 of 5173; 61.5%), ever HCV RNA positive (n = 3876), initiated HCV treatment (1693 of 3876; 43.7%), completed HCV treatment (1598 of 3876; 41.2%), follow-up HCV RNA test to allow SVR assessment (1195 of 3876; 30.8%), and cure (629 of 3876; 16.2%). The proportion that achieved SVR was 52.6% (629 of 1195). There were significant differences between regions at each stage of the continuum (P <0.0001). Conclusions In the proposed HCV continuum of care for HIV/HCV-coinfected individuals, we found major gaps at all stages, with almost 20% of anti-HCV-positive individuals having no documented HCV RNA test and a low proportion achieving SVR, in the pre-DAA era.
Subject: continuum of care
Europe
HIV/HCV coinfection
sustained virological response
treatment
HIV
ERA
INTERFERON
INFECTION
PEOPLE
RATES
DEATH
3121 Internal medicine
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