High-Dose Vitamin D Supplementation Does Not Prevent Allergic Sensitization of Infants

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Rosendahl , J , Pelkonen , A S , Helve , O , Hauta-alus , H , Holmlund-Suila , E , Valkama , S , Enlund-Cerullo , M , Viljakainen , H , Hytinantti , T , Mäkitie , O , Andersson , S & Mäkelä , M J 2019 , ' High-Dose Vitamin D Supplementation Does Not Prevent Allergic Sensitization of Infants ' , The Journal of Pediatrics , vol. 209 , pp. 139-+ . https://doi.org/10.1016/j.jpeds.2019.02.021

Title: High-Dose Vitamin D Supplementation Does Not Prevent Allergic Sensitization of Infants
Author: Rosendahl, Jenni; Pelkonen, Anna S.; Helve, Otto; Hauta-alus, Helena; Holmlund-Suila, Elisa; Valkama, Saara; Enlund-Cerullo, Maria; Viljakainen, Heli; Hytinantti, Timo; Mäkitie, Outi; Andersson, Sture; Mäkelä, Mika J.
Contributor: University of Helsinki, Clinicum
University of Helsinki, Department of Dermatology, Allergology and Venereology
University of Helsinki, Children's Hospital
University of Helsinki, Children's Hospital
University of Helsinki, Clinicum
University of Helsinki, Lastentautien yksikkö
University of Helsinki, Lastentautien yksikkö
University of Helsinki, Department of Food and Nutrition
University of Helsinki, Children's Hospital
University of Helsinki, HUS Children and Adolescents
University of Helsinki, Children's Hospital
University of Helsinki, Department of Dermatology, Allergology and Venereology
Date: 2019-06
Language: eng
Number of pages: 8
Belongs to series: The Journal of Pediatrics
ISSN: 0022-3476
URI: http://hdl.handle.net/10138/312883
Abstract: Objective To investigate the effect of vitamin D supplementation dose on allergic sensitization and allergic diseases in infants, and to evaluate whether vitamin D status in pregnancy and at birth are associated with infant allergy outcomes. Study design Altogether, 975 infants participated in a randomized, controlled trial of daily vitamin D supplementation of 10 mu g (400 IU) or 30 mu g (1200 IU) from the age of 2 weeks. At 12 months of age, food and aeroallergen IgE antibodies were measured, and the occurrence of allergic diseases and wheezing were evaluated. Results We found no differences between the vitamin D supplementation groups in food (OR, 0.98; 95% CI, 0.66-1.46) or aeroallergen sensitization at 12 months (OR, 0.76; 95% CI,0.34-1.71). Allergic diseases or wheezing did not differ between groups, except for milk allergy which occurred more often in infants administered 30 mu g vitamin D compared with the 10 mu g dose (OR, 2.23; 95% CI, 1.00-4.96). Infants with high cord blood 25-hydroxyvitamin D (>= 100 nmol/L) had a higher risk of food allergen sensitization compared with those with lower 25(OH)D concentration (75-99.9 nmol/L; OR, 2.00; 95% CI, 1.19-3.39). Conclusions High-dose vitamin D supplementation did not prevent allergic sensitization, allergic diseases, or wheezing during the first year of life. In contrast, we observed an increased risk of milk allergy in infants randomized to higher vitamin D supplementation, and an increased risk of allergic sensitization in infants with high cord blood vitamin D status, indicating a possible adverse effect of high concentrations of vitamin D.
Subject: SERUM 25-HYDROXYVITAMIN D
EARLY-CHILDHOOD
RISK
ASTHMA
BIRTH
INFECTIONS
PREGNANCY
DISEASE
COHORT
3123 Gynaecology and paediatrics
3121 General medicine, internal medicine and other clinical medicine
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