A within-sibling pair analysis of lifestyle behaviours and BMI z-score in the multi-centre I.Family study

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I Family consortium , Bogl , L H , Mehlig , K , Intemann , T , Masip , G , Keski-Rahkonen , A , Kaprio , J & Hebestreit , A 2019 , ' A within-sibling pair analysis of lifestyle behaviours and BMI z-score in the multi-centre I.Family study ' , Nutrition, Metabolism and Cardiovascular Diseases , vol. 29 , no. 6 , pp. 580-589 . https://doi.org/10.1016/j.numecd.2019.01.017

Title: A within-sibling pair analysis of lifestyle behaviours and BMI z-score in the multi-centre I.Family study
Author: I Family consortium; Bogl, L. H.; Mehlig, K.; Intemann, T.; Masip, G.; Keski-Rahkonen, A.; Kaprio, J.; Hebestreit, A.
Other contributor: University of Helsinki, Clinicum
University of Helsinki, Department of Public Health
University of Helsinki, Institute for Molecular Medicine Finland

Date: 2019-06
Language: eng
Number of pages: 10
Belongs to series: Nutrition, Metabolism and Cardiovascular Diseases
ISSN: 0939-4753
DOI: https://doi.org/10.1016/j.numecd.2019.01.017
URI: http://hdl.handle.net/10138/312885
Abstract: Background and aims: By investigating differences in lifestyle behaviours and BMI in sibling pairs, family-level confounding is minimized and causal inference is improved, compared to cross-sectional studies of unrelated children. Thus, we aimed to investigate within-sibling pair differences in different lifestyle behaviours and differences in BMI z-scores in children and adolesents. Methods and results: We examined three groups of sibling pairs 1) all same-sex sibling pairs with maximum 4 years age difference (n = 1209 pairs from 1072 families in 8 countries, mean age 10.7 years, standard deviation 2.4 years), 2) sibling pairs discordant for overweight (n = 262) and 3) twin pairs (n = 85). Usual dietary intake was estimated by 24-h recalls and time spent in light (LPA) and moderate-to-vigorous physical activity (MVPA) was measured by accelerometers. Screen time, sleep and dieting for weight loss were assessed by questionnaires. Within all 3 groups of sibling pairs, more time in MVPA was associated with lower BMI z-score. Higher energy intake was associated with higher BMI z-score within twin pairs and within all sibling pairs who were not currently dieting for weight loss. Regarding LPA, screen time or sleep duration, no or inconsistent associations were observed for the three groups of sibling pairs. Conclusions: MVPA and energy intake were associated with BMI differences within sibling and twin pairs growing up in the same home, thus independent of family-level confounding factors. Future studies should explore whether genetic variants regulating appetite or energy expenditure behaviours account for weight differences in sibling pairs. (C) 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
Subject: Overweight-discordant
Sibling pairs
Twin pairs
Body mass index
Energy intake
3121 General medicine, internal medicine and other clinical medicine
3142 Public health care science, environmental and occupational health

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