Second primary cancers in patients with acute lymphoblastic, chronic lymphocytic and hairy cell leukaemia

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Zheng , G , Chattopadhyay , S , Sud , A , Sundquist , K , Sundquist , J , Försti , A , Houlston , R , Hemminki , A & Hemminki , K 2019 , ' Second primary cancers in patients with acute lymphoblastic, chronic lymphocytic and hairy cell leukaemia ' , British Journal of Haematology , vol. 185 , no. 2 , pp. 232-239 . https://doi.org/10.1111/bjh.15777

Title: Second primary cancers in patients with acute lymphoblastic, chronic lymphocytic and hairy cell leukaemia
Author: Zheng, Guoqiao; Chattopadhyay, Subhayan; Sud, Amit; Sundquist, Kristina; Sundquist, Jan; Försti, Asta; Houlston, Richard; Hemminki, Akseli; Hemminki, Kari
Contributor: University of Helsinki, Department of Oncology
Date: 2019-04
Language: eng
Number of pages: 8
Belongs to series: British Journal of Haematology
ISSN: 0007-1048
URI: http://hdl.handle.net/10138/312889
Abstract: Improvement of survival in lymphocytic leukaemia has been accompanied by the occurrence of second primary cancer (SPCs). Based on Swedish Family Cancer Database, we applied bi-directional analyses in which relative risks (RRs) were calculated for any SPCs in patients with chronic lymphocytic leukaemia (CLL), acute lymphoblastic leukaemia (ALL) and hairy cell leukaemia (HCL) and the risks of these leukaemias as SPCs. After CLL, RRs were significant for 20 SPCs, and high for skin squamous cell cancer (2458 for insitu and 763 for invasive), Merkel cell carcinoma (1436), Hodgkin lymphoma (716) and Kaposi sarcoma (676). Conversely, 15 CLL cancer pairs were reciprocally increased. The increased risks were reciprocal for ALL and four cancers. RR for ALL was 1535 after myeloid neoplasia. HCL showed reciprocally increased RRs with non-Hodgkin lymphoma and melanoma. The concordance between RRs for bi-directional associations between CLL and different cancers, and HCL and different cancers was highly significant. For CLL (also for HCL), the bi-directional risks with skin cancers and other immune-related cancers suggest the probable involvement of immune dysfunction. For ALL, treatment may contribute to risks of multiple SPCs. Increased risk of ALL after haematological neoplasms may indicate bone marrow dysfunction. These findings may help guide treatment decisions and prognostic assessment.
Subject: B cell leukaemia
second cancers
immune suppression
bi-directional risk
mechanistic implication
RENAL-TRANSPLANTATION
FOLLOW-UP
MALIGNANCY
RISK
DISORDERS
MORTALITY
CARCINOMA
SECONDARY
LYMPHOMA
3122 Cancers
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