Craniomaxillofacial osteosarcoma - The role of surgical margins

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Kontio , R , Hagström , J , Lindholm , P , Böhling , T , Sampo , M , Mesimäki , K , Saarilahti , K , Koivunen , P & Mäkitie , A A 2019 , ' Craniomaxillofacial osteosarcoma - The role of surgical margins ' , Journal of Cranio-Maxillo-Facial Surgery , vol. 47 , no. 6 , pp. 922-925 .

Title: Craniomaxillofacial osteosarcoma - The role of surgical margins
Author: Kontio, R.; Hagström, J.; Lindholm, P.; Böhling, T.; Sampo, M.; Mesimäki, K.; Saarilahti, K.; Koivunen, P.; Mäkitie, A. A.
Contributor organization: Department of Oral and Maxillofacial Diseases
HUS Head and Neck Center
Oral and Maxillofacial Surgery
Department of Pathology
Tom Böhling / Principal Investigator
Department of Oncology
HUS Comprehensive Cancer Center
Department of Ophthalmology and Otorhinolaryngology
Korva-, nenä- ja kurkkutautien klinikka
Date: 2019-06
Language: eng
Number of pages: 4
Belongs to series: Journal of Cranio-Maxillo-Facial Surgery
ISSN: 1010-5182
Abstract: Background: Osteosarcomas (OS) in the craniomaxillofacial (CMF) region are typically diagnosed at later age than long-bone OS, but they are reported to have better 5-year survival. Curative treatment warrants wide surgical resection, which is often not possible in the CMF region. The purpose of this article is to present a nationwide series of CMF in Finland to discuss the role of surgery. Patients and methods: All 21 CMF OS patients managed in Finland from 1992 to 2009 were included. The mean age was 40 years (range 15e72). Data on patient and tumor characteristics, treatment modalities, and survival were recorded. All patients had a minimum follow-up of 5 years or until death. Results: OS was evenly represented in the mandible and maxillary bones, which together constituted 76% of all sites. Surgery with curative intent was carried out in 20 patients. Clear margins were achieved in only five cases. Eight (40%) of these 20 patients died due to OS, and their average survival time was 1.3 years. Seven (35%) out of the 20 patients received radiotherapy due to close/intralesional surgical margins, and four of them did not develop recurrences during the follow-up. Conclusions: The results suggest that postoperative radiotherapy may alter the prognosis in CMF OS, particularly in cases with close or intralesional margins. This may increase the survival rates achieved by prompt action in performing radical surgery. (C) 2019 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
Subject: Osteosarcoma
Head and neck
313 Dentistry
3126 Surgery, anesthesiology, intensive care, radiology
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion

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