Surgical treatment and prognosis of breast cancer in elderly - A population-based study

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Ojala , K , Meretoja , T J , Mattson , J & Leidenius , M H K 2019 , ' Surgical treatment and prognosis of breast cancer in elderly - A population-based study ' , European Journal of Surgical Oncology , vol. 45 , no. 6 , pp. 956-962 . https://doi.org/10.1016/j.ejso.2019.01.019

Title: Surgical treatment and prognosis of breast cancer in elderly - A population-based study
Author: Ojala, Kaisu; Meretoja, Tuomo J.; Mattson, Johanna; Leidenius, Marjut H. K.
Other contributor: University of Helsinki, HUS Comprehensive Cancer Center
University of Helsinki, HUS Comprehensive Cancer Center
University of Helsinki, University of Helsinki
University of Helsinki, University of Helsinki





Date: 2019-06
Language: eng
Number of pages: 7
Belongs to series: European Journal of Surgical Oncology
ISSN: 0748-7983
DOI: https://doi.org/10.1016/j.ejso.2019.01.019
URI: http://hdl.handle.net/10138/312910
Abstract: Background: The aim of this study was to investigate outcome of treatment in patients over 80 years of age with early breast cancer at the time of the diagnosis with special interest in surgical treatment. Materials and methods: Breast cancer patients older than 80 years of age, treated at the Breast Surgery Unit of Helsinki University Hospital in 2005-2010 were identified from electronic patient records. Patients were followed-up until the end of 2014. Patient and tumour characteristics, recurrences, co-morbidities and reasons for omission of surgery were collected from electronic patient records. Survival data was obtained from Finnish Cancer Registry. Results: 446 patients were eligible for the study: 401 (90%) received surgery. The median follow-up time was 52 months. In the entire study population, local and regional recurrences/disease progression were diagnosed in 16 (3.6%) and 6 (1.3%) patients, respectively. The five-year overall survival was 50.6% in the surgical treatment and only 15.2% in non-surgical treatment group, p <0.001. Also, the five-year breast cancer specific survival was significantly better in the patients with surgery, 82.0%, but 56.0% in the patients without surgery, p <0.001. There was no mortality related to the surgery, but 122 (30%) patients died within three years from surgery. Conclusion: Surgical treatment rate was high. OS and BCSS were better in surgically treated elderly patients. Local and regional disease control was excellent, probably due to high rate of surgical treatment. Surgical treatment also seemed safe in this elderly patient population. However, surgical overtreatment was obvious in some patients. (C) 2019 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
Subject: Breast cancer
Elderly
Surgery
OLDER WOMEN
CONSERVATIVE SURGERY
CONSERVING SURGERY
EUROPEAN-SOCIETY
AGE
RADIOTHERAPY
IRRADIATION
MORTALITY
ADHERENCE
DIAGNOSIS
3122 Cancers
3126 Surgery, anesthesiology, intensive care, radiology
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