Association between antibiotic treatment during pregnancy and infancy and the development of allergic diseases

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dc.contributor.author PASTURE EFRAIM Study Grp
dc.contributor.author Metzler, Stefanie
dc.contributor.author Frei, Remo
dc.contributor.author Schmausser-Hechfellner, Elisabeth
dc.contributor.author Pekkanen, Juha
dc.contributor.author Karvonen, Anne M.
dc.contributor.author Kirjavainen, Pirkka V.
dc.contributor.author Roduit, Caroline
dc.date.accessioned 2020-03-05T03:29:35Z
dc.date.available 2021-12-18T03:45:17Z
dc.date.issued 2019-06
dc.identifier.citation PASTURE EFRAIM Study Grp , Metzler , S , Frei , R , Schmausser-Hechfellner , E , Pekkanen , J , Karvonen , A M , Kirjavainen , P V & Roduit , C 2019 , ' Association between antibiotic treatment during pregnancy and infancy and the development of allergic diseases ' , Pediatric Allergy and Immunology , vol. 30 , no. 4 , pp. 423-433 . https://doi.org/10.1111/pai.13039
dc.identifier.other PURE: 126410991
dc.identifier.other PURE UUID: 69633669-e3a8-479a-b171-b28357112cdf
dc.identifier.other WOS: 000474809400004
dc.identifier.uri http://hdl.handle.net/10138/312916
dc.description.abstract Background: Allergies are a serious public health issue, and prevalences are rising worldwide. The role of antibiotics in the development of allergies has repeatedly been discussed, as results remain inconsistent. The aim of this study was to investigate the association between pre-and post-natal antibiotic exposure and subsequent development of allergies (atopic dermatitis, food allergy, asthma, atopic sensitization and allergic rhinitis). Methods: A total of 1080 children who participated in a European birth cohort study (PASTURE) were included in this analysis. Data on antibiotic exposure during pregnancy and/or first year of life and allergic diseases were collected by questionnaires from pregnancy up to 6 years of age and analysed by performing logistic regressions. To take into account reverse causation, we included models, where children with diagnosis or symptoms of the respective disease in the first year of life were excluded. Results: Antibiotic exposure in utero was significantly and positively associated with atopic dermatitis and food allergy. The strongest effect was on diseases with onset within the first year of life (for atopic dermatitis: aOR 1.66, 95% CI 1.11-2.48 and for food allergy: aOR 3.01, 95% CI 1.22-7.47). Antibiotics in the first year of life were positively associated with atopic dermatitis up to 4 years (aOR 2.73, 95% CI 1.66-4.49) and also suggested a dose-response relationship. A tendency was observed with asthma between 3 and 6 years (aOR 1.65, 95% CI 0.95-2.86). Conclusions: Our findings show positive associations between exposure to antibiotics and allergies, mainly atopic dermatitis and food allergy within the first year of life, after prenatal exposure, and atopic dermatitis and asthma after post-natal exposure to antibiotics in children born in rural settings. en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof Pediatric Allergy and Immunology
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject allergy
dc.subject antibiotics
dc.subject asthma
dc.subject atopic dermatitis
dc.subject children
dc.subject food allergy
dc.subject EARLY-LIFE EXPOSURE
dc.subject CHILDHOOD ASTHMA
dc.subject INTESTINAL MICROBIOTA
dc.subject ATOPIC SENSITIZATION
dc.subject BIRTH COHORT
dc.subject RISK
dc.subject INFECTIONS
dc.subject CHILDREN
dc.subject DIVERSITY
dc.subject ECZEMA
dc.subject 3123 Gynaecology and paediatrics
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Association between antibiotic treatment during pregnancy and infancy and the development of allergic diseases en
dc.type Article
dc.contributor.organization Department of Public Health
dc.contributor.organization University of Helsinki
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1111/pai.13039
dc.relation.issn 0905-6157
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion
dc.type.version publishedVersion

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