Gestational Diabetes But Not Prepregnancy Overweight Predicts for Cardiometabolic Markers in Offspring Twenty Years Later

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Kaseva , N , Vääräsmäki , M , Sundvall , J , Matinolli , H-M , Sipola , M , Tikanmäki , M , Heinonen , K , Lano , A , Wehkalampi , K , Wolke , D , Ruokonen , A , Andersson , S , Järvelin , M-R , Räikkönen , K , Eriksson , J G & Kajantie , E 2019 , ' Gestational Diabetes But Not Prepregnancy Overweight Predicts for Cardiometabolic Markers in Offspring Twenty Years Later ' , Journal of Clinical Endocrinology and Metabolism , vol. 104 , no. 7 , pp. 2785-2795 .

Title: Gestational Diabetes But Not Prepregnancy Overweight Predicts for Cardiometabolic Markers in Offspring Twenty Years Later
Author: Kaseva, Nina; Vääräsmäki, Marja; Sundvall, Jouko; Matinolli, Hanna-Maria; Sipola, Marika; Tikanmäki, Marjaana; Heinonen, Kati; Lano, Aulikki; Wehkalampi, Karoliina; Wolke, Dieter; Ruokonen, Aimo; Andersson, Sture; Järvelin, Marjo-Riitta; Räikkönen, Katri; Eriksson, Johan G.; Kajantie, Eero
Contributor organization: Department of Psychology and Logopedics
University Management
University of Helsinki
Lastenneurologian yksikkö
Children's Hospital
HUS Children and Adolescents
Johan Eriksson / Principal Investigator
Department of General Practice and Primary Health Care
Helsinki University Hospital Area
Lastentautien yksikkö
Developmental Psychology Research Group
Date: 2019-07
Language: eng
Number of pages: 11
Belongs to series: Journal of Clinical Endocrinology and Metabolism
ISSN: 0021-972X
Abstract: Context: Maternal gestational diabetes mellitus (GDM) and prepregnancy overweight/obesity [body mass index (BMI) >= 25 kg/m(2)] might adversely affect offspring cardiometabolic health. Objective: To assess the associations between maternal GDM and prepregnancy overweight/obesity with adult offspring cardiometabolic risk factors. Design: Longitudinal cohort study (ESTER Maternal Pregnancy Disorders Study and the Arvo Ylppo Longitudinal Study). Setting: Province of Uusimaa and Northern Finland. Participants: At a mean age of 24.1 +/- 1.3 years, we classified offspring as offspring of mothers with GDM regardless of the prepregnancy BMI (OGDM; n = 193); normoglycemic mothers with pre pregnancy overweight/obesity (ONO; n = 157); and normoglycemic mothers with prepregnancy BMI Main Outcome Measures: We assessed the cardiometabolic biomarkers from blood and measured the blood pressure at rest and heart rate. Results: Compared with the controls, the OGDM and ONO groups had greater fasting glucose (1.6%; 95% CI, 0.1% to 3.1%; and 2.3%; 95% CI, 0.5% to 4.3%, respectively) and insulin (12.7%; 95% CI, 4.4% to 21.9%; and 8.7%; 95% CI, 0.2% to 17.8%). These differences attenuated to nonsignificance when adjusted for confounders and/or current offspring characteristics, including BMI or body fat percentage. The OGDM group had lower SHBG (men, 12.4%; 95% CI, 20.2% to 3.9%; women, 33.2%; 95% CI, 46.3% to 16.8%), high-density lipoprotein (-6.6%; 95% CI, 10.9% to 2.2%), and apolipoprotein Al (-4.5%; 95% CI, 7.5% to 1.4%). These differences survived the adjustments. The heart rate and other biomarkers were similar among the groups. Conclusions: Adult offspring of mothers with GDM have increased markers of insulin resistance and a more atherogenic lipid profile. These were only partly explained by confounders or current offspring adiposity. Maternal prepregnancy overweight/obesity was associated with impaired offspring glucose regulation, which was explained by confounders and/or current adiposity.
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: draft

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