Gestational Diabetes But Not Prepregnancy Overweight Predicts for Cardiometabolic Markers in Offspring Twenty Years Later

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Kaseva , N , Vääräsmäki , M , Sundvall , J , Matinolli , H-M , Sipola , M , Tikanmäki , M , Heinonen , K , Lano , A , Wehkalampi , K , Wolke , D , Ruokonen , A , Andersson , S , Järvelin , M-R , Räikkönen , K , Eriksson , J G & Kajantie , E 2019 , ' Gestational Diabetes But Not Prepregnancy Overweight Predicts for Cardiometabolic Markers in Offspring Twenty Years Later ' , Journal of Clinical Endocrinology and Metabolism , vol. 104 , no. 7 , pp. 2785-2795 . https://doi.org/10.1210/jc.2018-02743

Title: Gestational Diabetes But Not Prepregnancy Overweight Predicts for Cardiometabolic Markers in Offspring Twenty Years Later
Author: Kaseva, Nina; Vääräsmäki, Marja; Sundvall, Jouko; Matinolli, Hanna-Maria; Sipola, Marika; Tikanmäki, Marjaana; Heinonen, Kati; Lano, Aulikki; Wehkalampi, Karoliina; Wolke, Dieter; Ruokonen, Aimo; Andersson, Sture; Järvelin, Marjo-Riitta; Räikkönen, Katri; Eriksson, Johan G.; Kajantie, Eero
Other contributor: University of Helsinki, Department of Psychology and Logopedics
University of Helsinki, Lastenneurologian yksikkö
University of Helsinki, University of Helsinki
University of Helsinki, University of Helsinki
University of Helsinki, Department of Psychology and Logopedics
University of Helsinki, Johan Eriksson / Principal Investigator
University of Helsinki, HUS Children and Adolescents











Date: 2019-07
Language: eng
Number of pages: 11
Belongs to series: Journal of Clinical Endocrinology and Metabolism
ISSN: 0021-972X
DOI: https://doi.org/10.1210/jc.2018-02743
URI: http://hdl.handle.net/10138/312921
Abstract: Context: Maternal gestational diabetes mellitus (GDM) and prepregnancy overweight/obesity [body mass index (BMI) >= 25 kg/m(2)] might adversely affect offspring cardiometabolic health. Objective: To assess the associations between maternal GDM and prepregnancy overweight/obesity with adult offspring cardiometabolic risk factors. Design: Longitudinal cohort study (ESTER Maternal Pregnancy Disorders Study and the Arvo Ylppo Longitudinal Study). Setting: Province of Uusimaa and Northern Finland. Participants: At a mean age of 24.1 +/- 1.3 years, we classified offspring as offspring of mothers with GDM regardless of the prepregnancy BMI (OGDM; n = 193); normoglycemic mothers with pre pregnancy overweight/obesity (ONO; n = 157); and normoglycemic mothers with prepregnancy BMI Main Outcome Measures: We assessed the cardiometabolic biomarkers from blood and measured the blood pressure at rest and heart rate. Results: Compared with the controls, the OGDM and ONO groups had greater fasting glucose (1.6%; 95% CI, 0.1% to 3.1%; and 2.3%; 95% CI, 0.5% to 4.3%, respectively) and insulin (12.7%; 95% CI, 4.4% to 21.9%; and 8.7%; 95% CI, 0.2% to 17.8%). These differences attenuated to nonsignificance when adjusted for confounders and/or current offspring characteristics, including BMI or body fat percentage. The OGDM group had lower SHBG (men, 12.4%; 95% CI, 20.2% to 3.9%; women, 33.2%; 95% CI, 46.3% to 16.8%), high-density lipoprotein (-6.6%; 95% CI, 10.9% to 2.2%), and apolipoprotein Al (-4.5%; 95% CI, 7.5% to 1.4%). These differences survived the adjustments. The heart rate and other biomarkers were similar among the groups. Conclusions: Adult offspring of mothers with GDM have increased markers of insulin resistance and a more atherogenic lipid profile. These were only partly explained by confounders or current offspring adiposity. Maternal prepregnancy overweight/obesity was associated with impaired offspring glucose regulation, which was explained by confounders and/or current adiposity.
Subject: BODY-MASS INDEX
WEIGHT-GAIN
METABOLIC SYNDROME
RISK-FACTORS
OBESITY
BORN
ASSOCIATIONS
PREGNANCY
CHILDREN
WOMEN
3121 Internal medicine
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