Older adults using multi-dose dispensing exposed to risks of potentially inappropriate medications

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Bobrova , V , Heinamäki , J , Honkanen , O , Desselle , S , Airaksinen , M & Volmer , D 2019 , ' Older adults using multi-dose dispensing exposed to risks of potentially inappropriate medications ' , Research in Social and Administrative Pharmacy , vol. 15 , no. 9 , pp. 1102-1106 . https://doi.org/10.1016/j.sapharm.2018.11.007

Title: Older adults using multi-dose dispensing exposed to risks of potentially inappropriate medications
Author: Bobrova, Veera; Heinamäki, Jyrki; Honkanen, Outi; Desselle, Shane; Airaksinen, Marja; Volmer, Daisy
Contributor organization: Division of Pharmacology and Pharmacotherapy
Helsinki One Health (HOH)
Drug Research Program
Clin­ical Phar­macy Group
Date: 2019-09
Language: eng
Number of pages: 5
Belongs to series: Research in Social and Administrative Pharmacy
ISSN: 1551-7411
DOI: https://doi.org/10.1016/j.sapharm.2018.11.007
URI: http://hdl.handle.net/10138/312930
Abstract: Background: Multi-dose dispensing (MDD) of medications is a health technology designed to promote medication adherence and patient safety. MDD has been used as an alternative to ordinary prescription dispensing for patients, mostly elderly with high medication use. Objective: To evaluate the initiation phase of the MDD service to older adults >= 65 years and assess wheter the medication use of the new MDD patients is appropriate in terms of drug related problems. Methods: The European Union EU(7)-PIM list and the Inxbase databases were used for identifying potentially inappropriate medications (PIMs) and drug-drug interactions (DDIs). The study sample consisted of a total of 208 patients aged 65-108 years who were involved in the MDD service (PharmaService Ltd.) in Finland in 2015-2016. Clinically significant differences of PIM and DDI occurrences were identified using a Pearson's chi-square test throughout the demographic groups under study. Results: Results demonstrate that for 81% of the study participants, at least one medication from the EU (7)-PIM list was prescribed, and up to 64% of PIMs were clinically significant. According to the Inxbase database, five patients (2.4%) were prescribed category D clinically significant DDIs. Additionally, 61% of the patients saw an increase in the number of medications prescribed within six months after the initial MDD order. Conclusions: The results suggest that the MDD service should be accompanied by a regular medication review tailored to specific patient groups (i.e., older patients) to avoid potential DRPs.
Subject: Estonia
Drug-related problems
Medication review
Medication safety
Multi-dose dispensing
317 Pharmacy
3142 Public health care science, environmental and occupational health
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion

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