Incidence, prevalence, and causes of death of patients with autoimmune hepatitis : A nationwide register-based cohort study in Finland

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Puustinen , L , Barner-Rasmussen , N , Pukkala , E & Farkkila , M 2019 , ' Incidence, prevalence, and causes of death of patients with autoimmune hepatitis : A nationwide register-based cohort study in Finland ' , Digestive and Liver Disease , vol. 51 , no. 9 , pp. 1294-1299 . https://doi.org/10.1016/j.dld.2019.01.015

Title: Incidence, prevalence, and causes of death of patients with autoimmune hepatitis : A nationwide register-based cohort study in Finland
Author: Puustinen, Lauri; Barner-Rasmussen, Nina; Pukkala, Eero; Farkkila, Martti
Contributor: University of Helsinki, Gastroenterologian yksikkö
University of Helsinki, HUS Abdominal Center
University of Helsinki, HUS Abdominal Center
Date: 2019-09
Language: eng
Number of pages: 6
Belongs to series: Digestive and Liver Disease
ISSN: 1590-8658
URI: http://hdl.handle.net/10138/312931
Abstract: Background: Epidemiological studies of autoimmune hepatitis are scarce and often based on single centre registries. Aims: We conducted a nationwide register study of incidence, prevalence, survival, and causes of death of autoimmune hepatitis patients in Finland. Methods: Autoimmune hepatitis cases 1995-2015 were retrieved from the national database of special reimbursements for drugs costs. Data on causes of death were retrieved from Statistics Finland. Results: After incomplete registration of AIH during the first years, the incidence of autoimmune hepatitis stabilised to 1.1/100,000 person-years (1.6 in women and 0.52 in men) in 2008-2015. The prevalence of autoimmune hepatitis at the end of 2015 was 14.3/100,000, 23.0/100,000 in women and 6.6/100,000 in men. The all-cause standardized mortality ratio (SMR) of autoimmune hepatitis patients was 1.81 (95% confidence interval (CI) 1.47-2.20). The SMR was increased in all age groups and in both sexes. The SMR for hepatocellular carcinoma was 20.6 (95% CI 10.3-36.8), and for digestive diseases in overall 13.5 (95% CI 8.2-20.8), constituting mainly from autoimmune hepatitis and liver cirrhosis. Conclusion: Incidence of autoimmune hepatitis has remained stable, with clear female predominance. Autoimmune hepatitis is associated with a markedly increased risk of death with hepatocellular cancer forming the greatest risk. (C) 2019 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
Subject: Autoimmune liver disease
Epidemiology
Mortality
INFLAMMATORY-BOWEL-DISEASE
HEPATOCELLULAR-CARCINOMA
CIRRHOSIS
DIAGNOSIS
AZATHIOPRINE
EPIDEMIOLOGY
CRITERIA
3121 General medicine, internal medicine and other clinical medicine
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