Biotechnology of health-promoting bacteria

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http://hdl.handle.net/10138/312932

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Douillard , F P & de Vos , W M 2019 , ' Biotechnology of health-promoting bacteria ' , Biotechnology Advances , vol. 37 , no. 6 , 107369 . https://doi.org/10.1016/j.biotechadv.2019.03.008

Title: Biotechnology of health-promoting bacteria
Author: Douillard, Francois P.; de Vos, Willem M.
Contributor: University of Helsinki, Food Hygiene and Environmental Health
University of Helsinki, Director and Common Matters
Date: 2019-11-01
Language: eng
Number of pages: 12
Belongs to series: Biotechnology Advances
ISSN: 0734-9750
URI: http://hdl.handle.net/10138/312932
Abstract: Over the last decade, there has been an increasing scientific and public interest in bacteria that may positively contribute to human gut health and well-being. This interest is reflected by the ever-increasing number of developed functional food products containing health-promoting bacteria and reaching the market place as well as by the growing revenue and profits of notably bacterial supplements worldwide. Traditionally, the origin of probiotic-marketed bacteria was limited to a rather small number of bacterial species that mostly belong to lactic acid bacteria and bifidobacteria. Intensifying research efforts on the human gut microbiome offered novel insights into the role of human gut microbiota in health and disease, while also providing a deep and increasingly comprehensive understanding of the bacterial communities present in this complex ecosystem and their interactions with the gut-liver-brain axis. This resulted in rational and systematic approaches to select novel health promoting bacteria or to engineer existing bacteria with enhanced probiotic properties. In parallel, the field of gut microbiomics developed into a fertile framework for the identification, isolation and characterization of a phylogenetically diverse array of health-promoting bacterial species, also called next-generation therapeutic bacteria. The present review will address these developments with specific attention for the selection and improvement of a selected number of health-promoting bacterial species and strains that are extensively studied or hold promise for future food or pharma product development.
Subject: Applied genomics
Gut microbiota
Next-generation therapeutic bacteria
Probiotics
COMPLETE GENOME SEQUENCE
LACTIC-ACID BACTERIA
BIFIDOBACTERIUM-BREVE UCC2003
LACTOBACILLUS-PLANTARUM WCFS1
HUMAN INTESTINAL MICROBIOTA
AKKERMANSIA-MUCINIPHILA
FAECALIBACTERIUM-PRAUSNITZII
BUTYRICICOCCUS-PULLICAECORUM
CLOSTRIDIUM-BUTYRICUM
GUT MICROBIOTA
1183 Plant biology, microbiology, virology
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