Risk of adult-onset asthma increases with the number of allergic multimorbidities and decreases with age

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Toppila-Salmi , S , Chanoine , S , Karjalainen , J , Pekkanen , J , Bousquet , J & Siroux , V 2019 , ' Risk of adult-onset asthma increases with the number of allergic multimorbidities and decreases with age ' , Allergy : European journal of allergy and clinical immunology , vol. 74 , no. 12 , pp. 2406-2416 . https://doi.org/10.1111/all.13971

Title: Risk of adult-onset asthma increases with the number of allergic multimorbidities and decreases with age
Author: Toppila-Salmi, Sanna; Chanoine, Sebastien; Karjalainen, Jussi; Pekkanen, Juha; Bousquet, Jean; Siroux, Valerie
Contributor: University of Helsinki, HUS Inflammation Center
University of Helsinki, Department of Public Health
Date: 2019-12
Language: eng
Number of pages: 11
Belongs to series: Allergy : European journal of allergy and clinical immunology
ISSN: 0105-4538
URI: http://hdl.handle.net/10138/312949
Abstract: Background The aim was to study the association between allergic multimorbidity and adult-onset asthma considering the number of allergic diseases and the age effect. Methods We used population-based data from Finnish national registers including 1205 adults over 30 years of age with recently diagnosed asthma (age range: 30-93), matched for gender, age, and living region with one or two controls (n = 2050). Allergic rhinitis (AR), allergic conjunctivitis (AC), and allergic dermatitis (AD) were defined from self-completed questionnaire. Conditional logistic regression adjusted on potential confounders (smoking, growing in countryside, childhood hospitalized infection/pneumonia, parental asthma/allergy, parental smoking, education level, professional training, number of siblings, and birth order) was applied to estimate the asthma risk associated with allergic multimorbidity. Results A total of 1118 cases with asthma and 1772 matched controls were included [mean (SD, min-max) 53 (11, 31-71) years, 37% men)]. AR, AC, and AD were reported by 50.2%, 39.6%, and 33.8%, respectively, among subjects with asthma and 26.1%, 20.0%, and 23.5%, respectively, among controls. Compared to nonatopics, adult-onset asthma increased with the number of allergic diseases; adjusted OR for asthma [95% CI] associated with 1, 2, and 3 allergic diseases was 1.95 [1.52-2.49], 2.87 [2.19-3.77], and 4.26 [3.07-5.90], respectively. The association between adult-onset asthma and >= 1 allergic multimorbidity decreased with increasing age (3.52 [2.51-4.94], 2.44 [1.74-3.42], and 1.68 [1.04-2.71]) in subjects <50 years, 50-62 years, and > 62 years, respectively (p for age*>= 1 allergic multimorbidity interaction, 0.002). Conclusions Adult-onset asthma was positively associated with the number of allergic diseases, and this association decreases with age.
Subject: Asthma
atopic dermatitis
epidemiology
ocular allergy
rhinitis
SENSITIZATION PATTERN
RHINITIS
PREVALENCE
ECZEMA
CONJUNCTIVITIS
ASSOCIATION
CHILDREN
MEDALL
3121 Internal medicine
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