Abdurakhmanova , S , Semenova , S , Piepponen , T P & Panula , P 2019 , ' Abnormal behavior, striatal dopamine turnover and opioid peptide gene expression in histamine-deficient mice ' , Genes, Brain and Behavior , vol. 18 , no. 8 , 12595 . https://doi.org/10.1111/gbb.12595
Title: | Abnormal behavior, striatal dopamine turnover and opioid peptide gene expression in histamine-deficient mice |
Author: | Abdurakhmanova, Shamsiiat; Semenova, Svetlana; Piepponen, T. Petteri; Panula, Pertti |
Contributor organization: | Department of Anatomy Medicum University of Helsinki Regenerative pharmacology group Drug Research Program Timo Petteri Piepponen / Principal Investigator University Management Division of Pharmacology and Pharmacotherapy Helsinki In Vivo Animal Imaging Platform (HAIP) Pertti Panula / Principal Investigator |
Date: | 2019-11 |
Language: | eng |
Number of pages: | 12 |
Belongs to series: | Genes, Brain and Behavior |
ISSN: | 1601-1848 |
DOI: | https://doi.org/10.1111/gbb.12595 |
URI: | http://hdl.handle.net/10138/312950 |
Abstract: | Hypothalamic histaminergic neurons regulate a variety of homeostatic, metabolic and cognitive functions. Recent data have suggested a modulatory role of histamine and histamine receptors in shaping striatal activity and connected the histaminergic system to neuropsychiatric disorders. We characterized exploratory behavior and striatal neurotransmission in mice lacking the histamine producing enzyme histidine decarboxylase (Hdc). The mutant mice showed a distinct behavioral pattern during exploration of novel environment, specifically, increased frequency of rearing seated against the wall, jumping and head/body shakes. This behavioral phenotype was associated with decreased levels of striatal dopamine and serotonin and increased level of dopamine metabolite DOPAC. Gene expression levels of dynorphin and enkephalin, opioids released by medium spiny neurons of striatal direct and indirect pathways respectively, were lower in Hdc mutant mice than in control animals. A low dose of amphetamine led to similar behavioral and biochemical outcomes in both genotypes. Increased striatal dopamine turnover was observed in Hdc KO mice after treatment with dopamine precursor l-Dopa. Overall, our study suggests a role for striatal dopamine and opioid peptides in formation of distinct behavioral phenotype of Hdc KO mice. |
Subject: |
dopamine
dynorphin enkephalin histidine decarboxylase knock out mice novelty-induced exploratory activity serotonin striatum H-3-RECEPTOR ANTAGONIST/INVERSE AGONIST DECARBOXYLASE KNOCKOUT MICE BRAIN HISTAMINE H3 RECEPTOR MESSENGER-RNA HISTIDINE METHAMPHETAMINE MODULATION INHIBITION H-3 3112 Neurosciences 3124 Neurology and psychiatry |
Peer reviewed: | Yes |
Usage restriction: | openAccess |
Self-archived version: | acceptedVersion |
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