Abnormal behavior, striatal dopamine turnover and opioid peptide gene expression in histamine-deficient mice

Show full item record



Permalink

http://hdl.handle.net/10138/312950

Citation

Abdurakhmanova , S , Semenova , S , Piepponen , T P & Panula , P 2019 , ' Abnormal behavior, striatal dopamine turnover and opioid peptide gene expression in histamine-deficient mice ' , Genes, Brain and Behavior , vol. 18 , no. 8 , 12595 . https://doi.org/10.1111/gbb.12595

Title: Abnormal behavior, striatal dopamine turnover and opioid peptide gene expression in histamine-deficient mice
Author: Abdurakhmanova, Shamsiiat; Semenova, Svetlana; Piepponen, T. Petteri; Panula, Pertti
Other contributor: University of Helsinki, Department of Anatomy
University of Helsinki, Department of Anatomy
University of Helsinki, Regenerative pharmacology group
University of Helsinki, Helsinki In Vivo Animal Imaging Platform (HAIP)









Date: 2019-11
Language: eng
Number of pages: 12
Belongs to series: Genes, Brain and Behavior
ISSN: 1601-1848
DOI: https://doi.org/10.1111/gbb.12595
URI: http://hdl.handle.net/10138/312950
Abstract: Hypothalamic histaminergic neurons regulate a variety of homeostatic, metabolic and cognitive functions. Recent data have suggested a modulatory role of histamine and histamine receptors in shaping striatal activity and connected the histaminergic system to neuropsychiatric disorders. We characterized exploratory behavior and striatal neurotransmission in mice lacking the histamine producing enzyme histidine decarboxylase (Hdc). The mutant mice showed a distinct behavioral pattern during exploration of novel environment, specifically, increased frequency of rearing seated against the wall, jumping and head/body shakes. This behavioral phenotype was associated with decreased levels of striatal dopamine and serotonin and increased level of dopamine metabolite DOPAC. Gene expression levels of dynorphin and enkephalin, opioids released by medium spiny neurons of striatal direct and indirect pathways respectively, were lower in Hdc mutant mice than in control animals. A low dose of amphetamine led to similar behavioral and biochemical outcomes in both genotypes. Increased striatal dopamine turnover was observed in Hdc KO mice after treatment with dopamine precursor l-Dopa. Overall, our study suggests a role for striatal dopamine and opioid peptides in formation of distinct behavioral phenotype of Hdc KO mice.
Subject: dopamine
dynorphin
enkephalin
histidine decarboxylase knock out mice
novelty-induced exploratory activity
serotonin
striatum
H-3-RECEPTOR ANTAGONIST/INVERSE AGONIST
DECARBOXYLASE KNOCKOUT MICE
BRAIN HISTAMINE
H3 RECEPTOR
MESSENGER-RNA
HISTIDINE
METHAMPHETAMINE
MODULATION
INHIBITION
H-3
3112 Neurosciences
3124 Neurology and psychiatry
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
Abnormal_behavi ... stamine_deficient_mice.pdf 1.157Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record