The effect of sildenafil on pleural and peritoneal effusions after the TCPC operation

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http://hdl.handle.net/10138/312951

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Koski , T K , Suominen , P K , Raissadati , A , Knihtilä , H M , Ojala , T H & Salminen , J T 2019 , ' The effect of sildenafil on pleural and peritoneal effusions after the TCPC operation ' , Acta Anaesthesiologica Scandinavica , vol. 63 , no. 10 , pp. 1384-1389 . https://doi.org/10.1111/aas.13431

Title: The effect of sildenafil on pleural and peritoneal effusions after the TCPC operation
Author: Koski, Tapio K.; Suominen, Pertti K.; Raissadati, Alireza; Knihtilä, Hanna M.; Ojala, Tiina H.; Salminen, Jukka T.
Contributor: University of Helsinki, Children's Hospital
University of Helsinki, HUS Children and Adolescents
University of Helsinki, HUS Children and Adolescents
University of Helsinki, University of Helsinki
University of Helsinki, HUS Children and Adolescents
University of Helsinki, HUS Children and Adolescents
Date: 2019-11
Language: eng
Number of pages: 6
Belongs to series: Acta Anaesthesiologica Scandinavica
ISSN: 0001-5172
URI: http://hdl.handle.net/10138/312951
Abstract: Background We evaluated whether the administration of sildenafil in children undergoing the TCPC operation shortened the interval from the operation to the removal of the pleural and peritoneal drains. Methods We retrospectively reviewed the data of 122 patients who had undergone the TCPC operation between 2004 and 2014. Patients were divided into two groups on the basis of their treatments. Sildenafil was orally administered pre-operatively in the morning of the procedure or within 24 hours after the TCPC operation to the sildenafil group (n = 48), which was compared to a control group (n = 60). Fourteen patients were excluded from the study. Results The primary outcome measure was the time from the operation to the removal of the drains. The study groups had similar demographics. The median [interquartile range] time for the removal of drains (sildenafil group 11 [8-19] vs control group 11 [7-16] d, P = .532) was comparable between the groups. The median [interquartile range] fluid balance on the first post-operative day was significantly higher (P = .001) in the sildenafil group compared with controls (47 [12-103] vs 7 [-6-67] mL kg(-1)). The first post-operative day fluid balance was a significant predictor for a prolonged need for drains in the multivariate analysis. Conclusions Sildenafil administration, pre-operatively or within 24 hours after the TCPC operation, did not reduce the required time for pleural and peritoneal drains but was associated with a significantly higher positive fluid balance.
Subject: congenital heart disease
univentricular heart
Fontan
sildenafil
Pleural
effusion
FONTAN PROCEDURE
EXTUBATION
DRAINAGE
STRATEGY
STAY
3126 Surgery, anesthesiology, intensive care, radiology
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